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Title: Lower degree of mineralization found in cortical bone of adolescent idiopathic
Authors: Yeung, HY
Qin, L
Hung, VW
Lee, KM
Guo, X 
Cheng, JCY
Issue Date: 2006
Source: Studies in health technology and informatics, 2006, v. 123, p. 599-604
Abstract: A lowered bone mineral density (BMD) was observed in trabecular bone in a significant number of AIS patients. The present study aims at investigating whether lower BMD is a systemic phenomenon, which would also be present in the cortical component of long bone. Subjects and Methods. 78 AIS girls (age:15-18y.o) with either moderate (Cobb: 20–40) or severe (Cobb: >40) curve and 44 age-matched controls were recruited. The BMD of the distal region and the mid-shaft of radius were measured with a multi-layer peripheral quantitative computed tomography (pQCT). The trabecular bone and cortical bone BMD and the morphology of mid-shaft were compared. Results. Both trabecular and cortical BMD in severe AIS group was significantly lower than the control by 8.7% and 1.7% (p<0.05 for both), respectively. However, the cortical bone area of the mid-shaft did not show any differences from the normal control subjects. Discussion. This study demonstrates a systemic low BMD including the cortical bone. It is suggested that AIS girls may have disturbance in mineralization and ossification during peripubertal growth.
Publisher: IOS Press
Journal: Studies in health technology and informatics 
ISSN: 0926-9630
Appears in Collections:Conference Paper

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