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Title: Electrospray ionization on solid substrates
Authors: So, PK
Hu, B
Yao, ZP 
Issue Date: 2014
Source: Mass spectrometry, 2014, v. 3, no. special issue, S0028, p. 1-8
Abstract: Development of electrospray ionization on solid substrates (solid-substrate ESI) avoids the clogging problem encountered in conventional capillary-based ESI, allows more convenient sampling and permits new applications. So far, solid-substrate ESI with various materials, e.g., metals, paper, wood, fibers and biological tissue, has been developed, and applications ranging from analysis of pure compounds to complex mixtures as well as in vivo study were demonstrated. Particularly, the capability of solid-substrate ESI in direct analysis of complex samples, e.g., biological fluids and foods, has significantly facilitated mass spectrometric analysis in real-life applications and led to increasingly important roles of these techniques nowadays. In this review, various solid-substrate ESI techniques and their applications are summarized and the prospects in this field are discussed.
Keywords: Electrospray ionization
Solid substrate
Ambient ionization
Direct analysis
In vivo study
Publisher: Nihon Shitsuryo Bunseki Gakkai,Mass Spectrometry Society of Japan
Journal: Mass spectrometry 
ISSN: 2187-137X
EISSN: 2186-5116
DOI: 10.5702/massspectrometry.S0028
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