Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62543
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorJiang, H-
dc.creatorQian, ZM-
dc.creatorXie, JX-
dc.date.accessioned2017-01-09T01:19:03Z-
dc.date.available2017-01-09T01:19:03Z-
dc.identifier.issn0439-755X-
dc.identifier.urihttp://hdl.handle.net/10397/62543-
dc.language.isozhen_US
dc.publisher科學出版社en_US
dc.rights© 2003 中国学术期刊电子杂志出版社。本内容的使用仅限于教育、科研之目的。en_US
dc.rights© 2003 China Academic Journal Electronic Publishing House. It is to be used strictly for educational and research purposes.en_US
dc.subjectIronen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectDivalent metal transporter 1en_US
dc.subjectSubstantia nigraen_US
dc.titleIncreased DMT1 expression and iron content in MPTP-treated C57BL/6 miceen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage571-
dc.identifier.epage576-
dc.identifier.volume55-
dc.identifier.issue5-
dcterms.abstract铁在帕金森病(Parkinson’s disease,PD)的发病机制中起着非常关键的作用,为了探讨PD中铁升高的机制,本实验观察了1-甲基-4-苯基-1,2,3,6--四氢吡啶(MPTP)处理小鼠黑质(substantia nigra,SN)内铁摄取及新的铁转运蛋白二价金属离子转运蛋白1(DMT1)的表达变化。结果表明:(1)MPTP处理组小鼠SN内铁染色增高,注射MPTP 7d组明显高于3 d组。(2)MPTP处理组小鼠,酪氨酸羟化酶(TH)免疫阳性细胞数目显著减少。(3)MPTP处理组小鼠,“-IRE”型 DMT1表达在各组中均增加,而“+IRE”型DMT1仅在MPTP处理后7 d才出现变化。上述结果提示,这种新发现的哺乳动物跨膜铁转运蛋白表达增加可能是引起MPTP处理小鼠SN中铁升高的关键因素,铁的升高进一步导致DA神经元的死亡。-
dcterms.abstractIron plays a key role in Parkinson’s disease (PD). To illustrate the mechanism underlyingthe increase of iron in substantia nigra (SN) in PD, changes of the expression of divalent metal transporter1 (DMT1 ) and iron content were examined in SN in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine(MPTP) treated mice using immunohistochemistry and histochemistry respectively. Following MPTP treat-ment for 3 d, elevated iron staining was found in SN. A further increase in iron content was observed after7 d. In these lesioned animals, tyrosine hydroxylase -immunoreactive DA neurons exhibited a decrease innumber and morphological changes as well. There were two isoforms of DMT1 expressed in SN of mice. Af-ter MPTP treatment, the expression of DMT1 without IRE form increased in either group, whereas DMT1with IRE form increased only after 7 d of MPTP treatment. These observations suggest that DMT1 is possiblyinvolved in the process of iron accumulation in SN of MPTP-treated mice, which might be responsible forthe subsequent death of DA neurons.-
dcterms.accessRightsopen accessen_US
dcterms.alternativeMPTP诱导小鼠黑质区铁摄取和DMT1表达增加-
dcterms.bibliographicCitation生理学报 (Acta physiological sinica), Oct. 2003, v. 55, no. 5, p. 571-576-
dcterms.isPartOf心理学报 (Acta psychologica sinica)-
dcterms.issued2003-
dc.identifier.rosgroupidr16364-
dc.description.ros2003-2004 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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