Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62448
Title: PDZ-reactive peptide activates Ephrin-B reverse signaling and inhibits neuronal chemotaxis
Authors: Yu, Y
Liu, M
Ng, TT
Huang, F
Nie, Y
Wang, R
Yao, ZP 
Li, Z
Xia, J
Issue Date: 2016
Publisher: American Chemical Society
Source: ACS chemical biology, 2016, v. 11, no. 1, p. 149-158 How to cite?
Journal: ACS chemical biology 
Abstract: Intracellular reactions on nonenzymatic proteins that activate cellular signals are rarely found. We report one example here that a designed peptide derivative undergoes a nucleophilic reaction specifically with a cytosolic PDZ protein inside cells. This reaction led to the activation of ephrin-B reverse signaling, which subsequently inhibited SDF-1 induced neuronal chemotaxis of human neuroblastoma cells and mouse cerebellar granule neurons. Our work provides direct evidence that PDZ-RGS3 bridges ephrin-B reverse signaling and SDF-1 induced G protein signaling for the first time.
URI: http://hdl.handle.net/10397/62448
ISSN: 1554-8929 (print)
1554-8937 (online)
DOI: 10.1021/acschembio.5b00889
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