Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62433
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dc.contributorDepartment of Biomedical Engineering-
dc.creatorXu, F-
dc.creatorMa, W-
dc.creatorHuang, Y-
dc.creatorQiu, Z-
dc.creatorSun, L-
dc.date.accessioned2016-12-19T09:00:41Z-
dc.date.available2016-12-19T09:00:41Z-
dc.identifier.issn1176-6328 (print)en_US
dc.identifier.urihttp://hdl.handle.net/10397/62433-
dc.language.isoenen_US
dc.publisherDove Medical Pressen_US
dc.rights© 2016 Xu et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).en_US
dc.rightsThe following publication: Xu, F., Ma, W., Huang, Y., Qiu, Z., & Sun, L. (2016). Deep brain stimulation of pallidal versus subthalamic for patients with Parkinson's disease: a meta-analysis of controlled clinical trials. Neuropsychiatric disease and treatment, 12, 1435-44 is available at http://dx.doi.org/10.2147/NDT.S105513en_US
dc.subjectParkinson diseaseen_US
dc.subjectDeep brain stimulationen_US
dc.subjectSubthalamic nucleusen_US
dc.subjectGlobus pallidus internusen_US
dc.titleDeep brain stimulation of pallidal versus subthalamic for patients with Parkinson's disease : a meta-analysis of controlled clinical trialsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1435en_US
dc.identifier.epage1444en_US
dc.identifier.volume12en_US
dc.identifier.doi10.2147/NDT.S105513en_US
dcterms.abstractBackground: Parkinson's disease (PD) is a common neurodegenerative disorder that affects many people every year. Deep brain stimulation (DBS) is an effective nonpharmacological method to treat PD motor symptoms. This meta-analysis was conducted to evaluate the efficacy of subthalamic nucleus (STN)-DBS versus globus pallidus internus (GPi)-DBS in treating advanced PD.-
dcterms.abstractMethods: Controlled clinical trials that compared STN-DBS to GPi-DBS for short-term treatment of PD in adults were researched up to November 2015. The primary outcomes were the Unified Parkinson's Disease Rating Scale Section (UPDRS) III score and the levodopa-equivalent dosage (LED) after DBS. The secondary outcomes were the UPDRS II score and the Beck Depression Inventory (BDI) score.-
dcterms.abstractResults: Totally, 13 studies containing 1,148 PD patients were included in this meta-analysis to compare STN-DBS versus GPi-DBS. During the off-medication state, the pooled weighted mean difference (WMD) of UPDRS III and II scores were -2.18 (95% CI =-5.11 to 0.74) and -1.96 (95% CI =-3.84 to -0.08), respectively. During the on-medication state, the pooled WMD of UPDRS III and II scores were 0.15 (95% CI =-1.14 to 1.44) and 1.01 (95% CI = 0.12 to 1.89), respectively. After DBS, the pooled WMD of LED and BDI were -254.48 (95% CI =-341.66) and 2.29 (95% CI = 0.83 to 3.75), respectively.-
dcterms.abstractConclusion: These results indicate that during the off-medication state, the STN-DBS might be superior to GPi-DBS in improving the motor function and activities of daily living for PD patients; but during the on-medication state, the opposite result is observed. Meanwhile, the STN-DBS is superior at reducing the LED, whereas the GPi-DBS shows a significantly greater reduction in BDI score after DBS.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationNeuropsychiatric disease and treatment, 2016, v. 12, p. 1435-1444-
dcterms.isPartOfNeuropsychiatric disease and treatment-
dcterms.issued2016-
dc.identifier.isiWOS:000378792300001-
dc.identifier.pmid27382286-
dc.identifier.rosgroupid2015004106-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validate201811_a bcmaen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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