Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62418
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dc.contributorSchool of Optometry-
dc.creatorDing, Z-
dc.creatorLi, J-
dc.creatorSpiegel, DP-
dc.creatorChen, Z-
dc.creatorChan, LYL-
dc.creatorLuo, G-
dc.creatorYuan, J-
dc.creatorDeng, D-
dc.creatorYu, M-
dc.creatorThompson, B-
dc.date.accessioned2016-12-19T09:00:38Z-
dc.date.available2016-12-19T09:00:38Z-
dc.identifier.urihttp://hdl.handle.net/10397/62418-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_US
dc.rightsThe following publication Ding, Z. et al. The effect of transcranial direct current stimulation on contrast sensitivity and visual evoked potential amplitude in adults with amblyopia. Sci. Rep. 6, 19280 (2016) is available at https://dx.doi.org/10.1038/srep19280en_US
dc.titleThe effect of transcranial direct current stimulation on contrast sensitivity and visual evoked potential amplitude in adults with amblyopiaen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume6-
dc.identifier.doi10.1038/srep19280-
dcterms.abstractAmblyopia is a neurodevelopmental disorder of vision that occurs when the visual cortex receives decorrelated inputs from the two eyes during an early critical period of development. Amblyopic eyes are subject to suppression from the fellow eye, generate weaker visual evoked potentials (VEPs) than fellow eyes and have multiple visual deficits including impairments in visual acuity and contrast sensitivity. Primate models and human psychophysics indicate that stronger suppression is associated with greater deficits in amblyopic eye contrast sensitivity and visual acuity. We tested whether transcranial direct current stimulation (tDCS) of the visual cortex would modulate VEP amplitude and contrast sensitivity in adults with amblyopia. tDCS can transiently alter cortical excitability and may influence suppressive neural interactions. Twenty-one patients with amblyopia and twenty-seven controls completed separate sessions of anodal (a-), cathodal (c-) and sham (s-) visual cortex tDCS. A-tDCS transiently and significantly increased VEP amplitudes for amblyopic, fellow and control eyes and contrast sensitivity for amblyopic and control eyes. C-tDCS decreased VEP amplitude and contrast sensitivity and s-tDCS had no effect. These results suggest that tDCS can modulate visual cortex responses to information from adult amblyopic eyes and provide a foundation for future clinical studies of tDCS in adults with amblyopia.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationScientific reports, 14 2016, v. 6, no. , p. 1-11-
dcterms.isPartOfScientific reports-
dcterms.issued2016-
dc.identifier.isiWOS:000368148200002-
dc.identifier.pmid26763954-
dc.identifier.eissn2045-2322-
dc.identifier.rosgroupid2015002024-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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