Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62200
Title: Synthesis of platinum(II) and palladium(II) complexes with 9,9-dihexyl-4,5-diazafluorene and their in vivo antitumour activity against Hep3B xenografted mice
Authors: Wang, QW
Lam, PL
Wong, RSM
Cheng, GYM
Lam, KH
Bian, ZX
Ho, CL
Feng, YH
Gambari, R
Lo, YH
Wong, WY 
Chui, CH
Keywords: Antitumour
In vivo
Palladium-diazafluorene complex
Platinum-diazafluorene complex
Issue Date: 2016
Publisher: Elsevier Masson
Source: European journal of medicinal chemistry, 2016, v. 124, p. 537-543 How to cite?
Journal: European journal of medicinal chemistry 
Abstract: Two complexes dichloro(9,9-dihexyl-4,5-diazafluorene)platinum(II) (Pt-DHF) and dichloro(9,9-dihexyl-4,5-diazafluorene)palladium(II) (Pd-DHF) were synthesized and their in vivo antitumour activity was investigated using an athymic nude mice model xenografted with human Hep3B carcinoma cells. Pt-DHF- and Pd-DHF-treated groups showed significant tumour growth inhibition (with about 9-fold and 3-fold tumour growth retardation) when compared with the vehicle control group. The liver toxicology effects on the animals of the two compounds were investigated. Pt-DHF and Pd-DHF-treated groups had a lower alanine transaminase and aspartate transaminase values than those of the vehicle treated group as the animals from the vehicle control group had very heavy hepatoma burden. We assume that both complexes could be further investigated as effective antitumour agents and it is worthwhile to study their underlying working mechanism.
URI: http://hdl.handle.net/10397/62200
ISSN: 0223-5234
EISSN: 1768-3254
DOI: 10.1016/j.ejmech.2016.08.033
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