Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/62040
DC Field | Value | Language |
---|---|---|
dc.contributor | Institute of Textiles and Clothing | - |
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Li, Z | - |
dc.creator | Liu, X | - |
dc.creator | Li, Y | - |
dc.creator | Lan, X | - |
dc.creator | Leung, PH | - |
dc.creator | Li, J | - |
dc.creator | Li, G | - |
dc.creator | Xie, M | - |
dc.creator | Han, Y | - |
dc.creator | Lin, X | - |
dc.date.accessioned | 2016-12-19T08:58:19Z | - |
dc.date.available | 2016-12-19T08:58:19Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/62040 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.rights | © The Author(s) 2016 | en_US |
dc.rights | The following publication Li, Z. et al. Composite Membranes of Recombinant Silkworm Antimicrobial Peptide and Poly (L-lactic Acid) (PLLA) for biomedical application. Sci. Rep. 6, 31149 (2016) is available at https://dx.doi.org/10.1038/srep31149 | en_US |
dc.title | Composite membranes of recombinant silkworm antimicrobial peptide and poly (L-lactic acid) (PLLA) for biomedical application | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 6 | - |
dc.identifier.doi | 10.1038/srep31149 | - |
dcterms.abstract | Antimicrobial peptides, produced by innate immune system of hosts in response to invading pathogens, are capable of fighting against a spectrum of bacteria, viruses, fungi, parasites and cancer cells. Here, a recombinant silkworm AMP Bmattacin2 from heterologous expression is studied, indicating a broad spectrum of antibacterial activity and showing selective killing ability towards skin and colon cancer cells over their normal cell counterparts. For the purpose of biomedical application, the electrospinning fabrication technique is employed to load Bmattacin2 into PLLA nanofibrous membrane. In addition to a good compatibility with the normal cells, Bmattacin2 loaded nanofibrous membranes demonstrate instant antibacterial effects and sustained anticancer effects. The cancer cell and bacteria targeting dynamics of recombinant Bmattacin2 are investigated. With these characteristics, PLLA/Bmattacin2 composite membranes have a great potential for developing novel biomedical applications such as cancer therapies and wound healing treatments. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Scientific reports, 9 2016, v. 6, no. , p. 1-12 | - |
dcterms.isPartOf | Scientific reports | - |
dcterms.issued | 2016 | - |
dc.identifier.isi | WOS:000381030300001 | - |
dc.identifier.scopus | 2-s2.0-84981313407 | - |
dc.identifier.pmid | 27503270 | - |
dc.identifier.ros | 2016000827 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.rosgroupid | 2016000821 | - |
dc.description.ros | 2016-2017 > Academic research: refereed > Publication in refereed journal | - |
dc.description.validate | 201804_a bcma | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Li_Membranes_Recombinant_Silkworm.pdf | 6.61 MB | Adobe PDF | View/Open |
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