Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62025
Title: FMLNCSIM : fuzzy measure-based lncRNA functional similarity calculation model
Authors: Chen, X
Huang, YA
Wang, XS
You, ZH
Chan, KCC 
Keywords: Directed acyclic graph
Disease
Functional similarity
Fuzzy measure
LncRNAs
Issue Date: 2016
Publisher: Impact Journals LLC
Source: Oncotarget, 2016, v. 7, no. 29, p. 45948-45958 How to cite?
Journal: Oncotarget 
Abstract: Accumulating experimental studies have indicated the influence of lncRNAs on various critical biological processes as well as disease development and progression. Calculating lncRNA functional similarity is of high value in inferring lncRNA functions and identifying potential lncRNA-disease associations. However, little effort has been attempt to measure the functional similarity among lncRNAs on a large scale. In this study, we developed a Fuzzy Measure-based LNCRNA functional SIMilarity calculation model (FMLNCSIM) based on the assumption that functionally similar lncRNAs tend to be associated with similar diseases. The performance improvement of FMLNCSIM mainly comes from the combination of information content and the concept of fuzzy measure, which was applied to the directed acyclic graphs of disease MeSH descriptors. To evaluate the effectiveness of FMLNCSIM, we further combined it with the previously proposed model of Laplacian Regularized Least Squares for lncRNA-Disease Association (LRLSLDA). As a result, the integrated model, LRLSLDAFMLNCSIM, achieve good performance in the frameworks of global LOOCV (AUCs of 0.8266 and 0.9338 based on LncRNADisease and MNDR database) and 5-fold cross validation (average AUCs of 0.7979 and 0.9237 based on LncRNADisease and MNDR database), which significantly improve the performance of previous classical models. It is anticipated that FMLNCSIM could be used for searching functionally similar lncRNAs and inferring lncRNA functions in the future researches.
URI: http://hdl.handle.net/10397/62025
ISSN: 1949-2553
DOI: 10.18632/oncotarget.10008
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

28
Last Week
2
Last month
Citations as of Nov 9, 2017

WEB OF SCIENCETM
Citations

24
Last Week
1
Last month
Citations as of Nov 17, 2017

Page view(s)

50
Last Week
1
Last month
Checked on Nov 12, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.