Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61936
Title: Metagenomic analysis revealing Antibiotic Resistance Genes (ARGs) and their genetic compartments in the Tibetan environment
Authors: Chen, B
Yuan, K
Chen, X
Yang, Y
Zhang, T
Wang, Y
Luan, T
Zou, S
Li, X 
Issue Date: 2016
Publisher: American Chemical Society
Source: Environmental science & technology, 2016, v. 50, no. 13, p. 6670-6679 How to cite?
Journal: Environmental science & technology 
Abstract: Comprehensive profiles of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in a minimally impacted environment are essential to understanding the evolution and dissemination of modern antibiotic resistance. Chemical analyses of the samples collected from Tibet demonstrated that the region under investigation was almost devoid of anthropogenic antibiotics. The soils, animal wastes, and sediments were different from each other in terms of bacterial community structures, and in the typical profiles of ARGs and MGEs. Diverse ARGs that encoded resistance to common antibiotics (e.g., beta-lactams, fluoroquinolones, etc.) were found mainly via an efflux mechanism completely distinct from modern antibiotic resistome. In addition, a very small fraction of ARGs in the Tibetan environment were carried by MGEs, indicating the low potential of these ARGs to be transferred among bacteria. In comparison to the ARG profiles in relatively pristine Tibet, contemporary ARGs and MGEs in human-impacted environments have evolved substantially since the broad use of anthropogenic antibiotics.
URI: http://hdl.handle.net/10397/61936
ISSN: 0013-936X
EISSN: 1520-5851
DOI: 10.1021/acs.est.6b00619
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