Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61935
Title: Multifunction of chrysin in Parkinson's model : anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B
Authors: Guo, B
Zheng, C
Cai, W
Cheng, J
Wang, H
Li, H
Sun, Y
Cui, W
Wang, Y
Han, Y 
Lee, SMY
Zhang, Z
Keywords: Chrysin
MAO-B
MEF2D
Neuroprotection
Parkinson's disease
Issue Date: 2016
Publisher: American Chemical Society
Source: Journal of agricultural and food chemistry, 2016, v. 64, no. 26, p. 5324-5333 How to cite?
Journal: Journal of agricultural and food chemistry 
Abstract: Chrysin, a flavonoid compound existing in several plants, is applied as a dietary supplement because of its beneficial effects on general human health and alleviation of neurological disorders. However, mechanisms underlying neuroprotection of chrysin has not been fully elucidated, and the effects of chrysin on the Parkinson's disease (PD) model in vivo have not been investigated. It is here shown that chrysin protects primary granular neurons against 1-methyl-4-phenylpyridinium ion insult via antiapoptosis by reversing the dysregulated expression of Bcl-2, Bax, and caspase 3. The mechanisms also involved activating transcriptional factor myocyte enhancer factor 2D (MEF2D) via regulation of AKT-GSK3β signaling. In this in vivo model of PD, chrysin rescued the dopaminergic neurons loss and alleviated the decrease in dopamine level induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Moreover, chrysin markedly inhibited monoamine oxidase-B activity in vitro and in vivo. In conclusion, chrysin exerts beneficial effects to PD, possibly through multitarget mechanisms including antineuronal apoptosis, activation of the AKT-GSK3β/MEF2D pathway, and inhibition of the MAO-B activity.
URI: http://hdl.handle.net/10397/61935
ISSN: 0021-8561
DOI: 10.1021/acs.jafc.6b01707
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