Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61916
Title: Ribosome-inactivating proteins from root tubers and seeds of Trichosan-thes kirilowii and other Trichosanthes species
Authors: Ye, X
Ng, CCW
Wong, JH
Ng, TB
Chan, GHH
Guan, S
Sha, O
Keywords: Anti-HIV-1
Anti-HSV-1
Anticancer
Ribosome-inactivating proteins
Trichosanthes kirilowii
Issue Date: 2016
Publisher: Bentham Science Publishers
Source: Protein and peptide letters, 2016, v. 23, no. 8, p. 699-706 How to cite?
Journal: Protein and peptide letters 
Abstract: Ribosome-inactivating proteins have been isolated from Trichosanthes kirilowii root tubers and seeds, including trichosanthin, karasurin and T 33 from root tubers and trichosanthrip, trichokirin, alpha-kirilowin, beta-kirilowin and trichoanguin from seeds. The aforementioned proteins show structural and functional similarities. Among them trichosanthin is the best known and most intensely studied. Trichosanthin manifests anticancer activity in vitro and in tumor bearing mice against a variety of cancers/cancer cell lines. It also exhibits anti-HIV-1 and anti-HSV-1 activities. Trichosanthin has been found to be useful for treatment of cesarean scar pregnancies and ectopic pregnancy, and for preventing acute rejection of major histocompatibility complex-mismatched mouse skin allograft. Trichosanthin selectively lesions some neurons and thus can be used in neuroscience research.
URI: http://hdl.handle.net/10397/61916
ISSN: 0929-8665
EISSN: 1875-5305
DOI: 10.2174/0929866523666160526130220
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