Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61470
Title: Exploiting aryl mesylates and tosylates in catalytic mono-α-arylation of aryl- and heteroarylketones
Authors: Fu, WC
So, CM
Yuen, OY
Lee, ITC
Kwong, FY 
Issue Date: 2016
Publisher: American Chemical Society
Source: Organic letters, 2016, v. 18, no. 8, p. 1872-1875 How to cite?
Journal: Organic letters 
Abstract: The first general palladium catalyst for the catalytic mono-α-arylation of aryl- and heteroarylketones with aryl mesylates and tosylates is described. The newly developed indolyl-derived phosphine ligand L7 has been identified to promote this reaction efficiently. The key to success is attributed to the enhanced steric congestion of the catalyst and effective oxidative addition of the C(Ar)-OMs bond. In the presence of Pd(OAc)2 (0.25-2.5 mol %) and L7, selective monoarylations are achieved with ample reaction scope and product yields up to 95%. Importantly, we demonstrated the applicability of this protocol with the modification of biological phenolic compounds, rendering it amenable for functionalization of phenolic (pro)drugs.
URI: http://hdl.handle.net/10397/61470
ISSN: 1523-7060
EISSN: 1523-7052
DOI: 10.1021/acs.orglett.6b00643
Appears in Collections:Journal/Magazine Article

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