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Title: Optical fiber LPG biosensor integrated microfluidic chip for ultrasensitive glucose detection
Authors: Yin, MJ
Huang, B
Gao, S
Zhang, AP 
Ye, X
Keywords: Biological sensing and sensors
Fiber optics sensors
Issue Date: 2016
Publisher: Optical Society of America
Source: Biomedical optics express, 2016, v. 7, no. 5, 259792, p. 2067-2077 How to cite?
Journal: Biomedical optics express 
Abstract: An optical fiber sensor integrated microfluidic chip is presented for ultrasensitive detection of glucose. A long-period grating (LPG) inscribed in a small-diameter single-mode fiber (SDSMF) is employed as an optical refractive-index (RI) sensor. With the layer-by-layer (LbL) selfassembly technique, poly (ethylenimine) (PEI) and poly (acrylic acid) (PAA) multilayer film is deposited on the SDSMF-LPG sensor for both supporting and signal enhancement, and then a glucose oxidase (GOD) layer is immobilized on the outer layer for glucose sensing. A microfluidic chip for glucose detection is fabricated after embedding the SDSMF-LPG biosensor into the microchannel of the chip. Experimental results reveal that the SDSMF-LPG biosensor based on such a hybrid sensing film can ultrasensitively detect glucose concentration as low as 1 nM. After integration into the microfluidic chip, the detection range of the sensor is extended from 2 μM to 10 μM, and the response time is remarkablely shortened from 6 minutes to 70 seconds.
ISSN: 2156-7085
DOI: 10.1364/BOE.7.002067
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