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dc.contributorDepartment of Health Technology and Informatics-
dc.contributorSchool of Optometry-
dc.creatorFan, Q-
dc.creatorVerhoeven, VJM-
dc.creatorWojciechowski, R-
dc.creatorBarathi, VA-
dc.creatorHysi, PG-
dc.creatorGuggenheim, JA-
dc.creatorHohn, R-
dc.creatorVitart, V-
dc.creatorKhawaja, AP-
dc.creatorYamashiro, K-
dc.creatorHosseini, SM-
dc.creatorMeitinger, T-
dc.creatorRied, JS-
dc.creatorGieger, C-
dc.creatorPortas, L-
dc.creatorvan Leeuwen, EM-
dc.creatorAmin, N-
dc.creatorUitterlinden, AG-
dc.creatorRivadeneira, F-
dc.creatorHofman, A-
dc.creatorVingerling, JR-
dc.creatorKlaver, CCW-
dc.creatorWang, YX-
dc.creatorWang, X-
dc.creatorBoh, THE-
dc.creatorIkram, MK-
dc.creatorSabanayagam, C-
dc.creatorGupta, P-
dc.creatorTan, V-
dc.creatorZhou, L-
dc.creatorHo, CEH-
dc.creatorLim, W-
dc.creatorSaw, SM-
dc.creatorBeuerman, RW-
dc.creatorSiantar, R-
dc.creatorTai, ES-
dc.creatorVithana, E-
dc.creatorMihailov, E-
dc.creatorKhor, CC-
dc.creatorHayward, C-
dc.creatorLuben, RN-
dc.creatorFoster, PJ-
dc.creatorKlein, BEK-
dc.creatorRahi, JS-
dc.creatorKlein, R-
dc.creatorWong, HS-
dc.creatorMitchell, P-
dc.creatorMetspalu, A-
dc.creatorAung, T-
dc.creatorYoung, TL-
dc.creatorHe, M-
dc.creatorParssinen, O-
dc.creatorvan Duijn, CM-
dc.creatorWang, JJ-
dc.creatorKorobelnik, JF-
dc.creatorWilliams, C-
dc.creatorJonas, JB-
dc.creatorTeo, YY-
dc.creatorMacKey, DA-
dc.creatorOexle, K-
dc.creatorYoshimura, N-
dc.creatorPaterson, AD-
dc.creatorPfeiffer, N-
dc.creatorWong, TY-
dc.creatorBaird, PN-
dc.creatorKemp, JP-
dc.creatorStambolian, D-
dc.creatorWilson, JEB-
dc.creatorCheng, CY-
dc.creatorHammond, CJ-
dc.creatorTimpson, NJ-
dc.creatorSmith, GD-
dc.creatorCraig, JE-
dc.creatorBurdon, KP-
dc.creatorFogarty, RD-
dc.creatorLehtimaki, T-
dc.creatorIyengar, SK-
dc.creatorChew, E-
dc.creatorJanmahasatian, S-
dc.creatorMartin, NG-
dc.creatorMacGregor, S-
dc.creatorXu, L-
dc.creatorSchache, M-
dc.creatorNangia, V-
dc.creatorPanda-Jonas, S-
dc.creatorWright, AF-
dc.creatorLu, Y-
dc.creatorFondran, JR-
dc.creatorLass, JH-
dc.creatorFeng, S-
dc.creatorZhao, JH-
dc.creatorKhaw, KT-
dc.creatorWareham, NJ-
dc.creatorRantanen, T-
dc.creatorKaprio, J-
dc.creatorPang, CP-
dc.creatorChen, LJ-
dc.creatorHaller, T-
dc.creatorTam, PO-
dc.creatorJhanji, V-
dc.creatorYoung, AL-
dc.creatorDoring, A-
dc.creatorRaffel, LJ-
dc.creatorCotch, MF-
dc.creatorLi, X-
dc.creatorYip, SP-
dc.creatorYap, MKH-
dc.creatorBiino, G-
dc.creatorXie, J-
dc.creatorVaccargiu, S-
dc.creatorFossarello, M-
dc.creatorFleck, B-
dc.creatorYazar, S-
dc.creatorTideman, JWL-
dc.creatorTedja, M-
dc.creatorDeangelis, MM-
dc.creatorMorrison, M-
dc.creatorFarrer, L-
dc.creatorZhou, X-
dc.creatorDelcourt, C-
dc.creatorChen, W-
dc.creatorMizuki, N-
dc.creatorMeguro, A-
dc.creatorMakela, KM-
dc.creatorPirastu, M-
dc.creatorWedenoja, J-
dc.creatorGharahkhani, P-
dc.creatorVenturini, C-
dc.creatorMiyake, M-
dc.creatorHewitt, AW-
dc.creatorGuo, X-
dc.creatorMazur, J-
dc.creatorHuffman, JE-
dc.creatorWilliams, KM-
dc.creatorPolasek, O-
dc.creatorCampbell, H-
dc.creatorRudan, I-
dc.creatorVatavuk, Z-
dc.creatorWilson, JF-
dc.creatorJoshi, PK-
dc.creatorMcMahon, G-
dc.creatorSt Pourcain, B-
dc.creatorEvans, DM-
dc.creatorSimpson, CL-
dc.creatorSchwantes-An, TH-
dc.creatorIgo, RP-
dc.creatorMirshahi, A-
dc.creatorCougnard-Gregoire, A-
dc.creatorBellenguez, C-
dc.creatorBlettner, M-
dc.creatorRaitakari, O-
dc.creatorKahonen, M-
dc.creatorSeppala, I-
dc.creatorZeller, T-
dc.date.accessioned2016-12-19T08:55:28Z-
dc.date.available2016-12-19T08:55:28Z-
dc.identifier.urihttp://hdl.handle.net/10397/61313-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_US
dc.rightsThe following publication Fan, Q. et al. Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error. Nat. Commun. 7:11008, 1-12 is available at https://dx.doi.org/10.1038/ncomms11008en_US
dc.titleMeta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive erroren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume7en_US
dc.identifier.doi10.1038/ncomms11008en_US
dcterms.abstractMyopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationNature communications, 2016, v. 7, 11008-
dcterms.isPartOfNature communications-
dcterms.issued2016-
dc.identifier.isiWOS:000373804800001-
dc.identifier.scopus2-s2.0-84962655499-
dc.identifier.pmid27020472-
dc.identifier.eissn2041-1723en_US
dc.identifier.rosgroupid2015003387-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journalen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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