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Title: Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride
Authors: Lam, KH
Lee, KKH
Kok, SHL
Wong, RSM
Lau, FY
Cheng, GYM
Wong, WY
Tong, SW
Chan, KW
Chan, RYK
Tang, JCO 
Cheng, CH
Hau, DKP
Bian, ZX
Gambari, R
Chui, CH
Keywords: 2-Formyl-8-hydroxy-quinolinium chloride
Diethylnitrosamine-induced hepatocarcinogenesis
Hepatoma xenograft
Issue Date: 2016
Publisher: Elsevier Masson
Source: Biomedicine and pharmacotherapy, 2016, v. 80, p. 145-150 How to cite?
Journal: Biomedicine and pharmacotherapy 
Abstract: Tumour growth is closely related to the development of new blood vessels to supply oxygen and nutrients to cancer cells. Without the neovascular formation, tumour volumes cannot increase and undergo metastasis. Antiangiogenesis is one of the most promising approaches for antitumour therapy. The exploration of new antiangiogenic agents would be helpful in antitumour therapy. Quinoline is an aromatic nitrogen compound characterized by a double-ring structure which exhibits a benzene ring fused to pyridine at two adjacent carbon atoms. The high stability of quinoline makes it preferable in a variety of therapeutic and pharmaceutical applications, including antitumour treatment. This work is to examine the potential antiangiogenic activity of the synthetic compound 2-Formyl-8-hydroxy-quinolinium chloride. We found that 2-Formyl-8-hydroxy-quinolinium chloride could inhibit the growth of human umbilical vein endothelial cells in vitro. Using the diethylnitrosamine-induced hepatocarcinogenesis model, 2-Formyl-8-hydroxy-quinolinium chloride showed strong antiangiogenic activity. Furthermore, 2-Formyl-8-hydroxy-quinolinium chloride could inhibit the growth of large Hep3B xenografted tumour from the nude mice. We assume that 2-Formyl-8-hydroxy-quinolinium chloride could be a potential antiangiogenic and antitumour agent and it is worthwhile to further study its underlying working mechanism.
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2016.03.014
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