Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61044
Title: Effect of continuous propofol infusion in rat on tau phosphorylation with or without temperature control
Authors: Huang, C
Ng, OTW
Ho, YS 
Irwin, MG
Chang, RCC
Wong, GTC
Keywords: Hypothermia
Propofol
Protein kinases
Tau phosphorylation
Issue Date: 2016
Publisher: IOS Press
Source: Journal of alzheimer's disease, 2016, v. 51, no. 1, p. 213-226 How to cite?
Journal: Journal of alzheimer's disease 
Abstract: Several studies suggest a relationship between anesthesia-induced tau hyperphosphorylation and the development of postoperative cognitive dysfunction. This study further characterized the effects of continuous propofol infusion on tau protein phosphorylation in rats, with or without temperature control. Propofol was administered intravenously to 8-10-week-old male Sprague-Dawley rats and infused to the loss of the righting reflex for 2 h continuously. Proteins from cortex and hippocampus were examined by western blot and immunohistochemistry. Rectal temperature was significantly decreased during propofol infusion. Propofol with hypothermia significantly increased phosphorylation of tau at AT8, AT180, Thr205, and Ser199 in cortex and hippocampus except Ser396. With temperature maintenance, propofol still induced significant elevation of AT8, Thr205, and Ser199 in cortex and hippocampus; however, increase of AT180 and Ser396 was only found in hippocampus and cortex, respectively. Differential effects of propofol with or without hypothermia on multiple tau related kinases, such as Akt/GSK3β, MAPK pathways, or phosphatase (PP2A), were demonstrated in region-specific manner. These findings indicated that propofol increased tau phosphorylation under both normothermic and hypothermic conditions, and temperature control could partially attenuate the hyperphosphorylation of tau. Further studies are warranted to determine the long-term impact of propofol on the tau pathology and cognitive functions.
URI: http://hdl.handle.net/10397/61044
ISSN: 1387-2877
EISSN: 1875-8908
DOI: 10.3233/JAD-150645
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