Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/60966
Title: Catalytic asymmetric ring-opening reactions of aziridines with 3-aryl-oxindoles
Authors: Wang, L
Li, D
Yang, D
Wang, K
Wang, J
Wang, P
Su, W
Wang, R
Keywords: 3,3′-fluorinated-binol
Aziridines
Magnesium catalysis
Oxindoles
Ring-opening reactions
Issue Date: 2016
Publisher: Wiley-VCH
Source: Chemistry, an Asian journal, 2016, v. 11, no. 5, p. 691-695 How to cite?
Journal: Chemistry, an Asian journal 
Abstract: A highly enantioselective ring-opening alkylation reaction between 3-aryl-oxindole and N-(2-picolinoyl) aziridine has been realized for the first time. The reaction is efficiently mediated by a simple in-situ-generated magnesium catalyst and 3,3′-fluorinated-BINOL (BINOL=1,1′-binaphthalene-2,2′-diol) has been identified as a powerful chiral ligand. Notably, the fluorine atom on the chiral ligand plays a key role in providing the desired chiral 3-alkyl-3-aryl oxindoles with excellent enantioselectivities.
URI: http://hdl.handle.net/10397/60966
ISSN: 1861-4728 (print)
1861-471X (online)
DOI: 10.1002/asia.201501369
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