Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/60950
Title: Four complement factor H gene polymorphisms in association with AMD : a meta-analysis
Authors: Liao, X
Lan, CJ
Cheuk, IWY
Tan, QQ
Keywords: Complement factor H
Macular degeneration
Meta-analysis
Polymorphism
Issue Date: 2016
Publisher: Elsevier
Source: Archives of gerontology and geriatrics, 2016, v. 64, p. 123-129 How to cite?
Journal: Archives of gerontology and geriatrics 
Abstract: Aim: To investigate the possible association between CFH gene polymorphisms -543G > A (rs1410996), A473A (rs2274700), -257C > T (rs3753394), IVS15 (rs1329428) and AMD risk.
Methods: We searched the published literature in the Medline and Scopus from inception to May 2015. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.
Results: Nineteen studies with a total of 10,676 subjects were included in the present meta-analysis. A statistical significant association was observed between AMD risk and CFH -543G > A polymorphism with OR of 1.77 (95% CI, 1.47-2.12), 2.24 (95% CI, 1.71-2.94), 0.49 (95% CI, 0.38-0.62) and 0.25 (95% CI, 0.18-0.37) in additive, dominant, recessive and codominant models, respectively. Similar results were obtained in polymorphisms A473A, -257C > T, IVS15. Furthermore, stratified analysis for ethnicity showed a significantly strong association between -543G > A, A473A polymorphisms and AMD risk.
Conclusion: The present meta-analysis suggested that CFH -543G > A, A473A, -257C > T, and IVS15 polymorphisms might be moderately associated with AMD risk. This conclusion warrants confirmation by further studies.
URI: http://hdl.handle.net/10397/60950
ISSN: 0167-4943 (print)
1872-6976 (online)
DOI: 10.1016/j.archger.2016.01.011
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