Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/60778
Title: Ion-tagged synthesis of an oligoribonucleotide pentamer — the continuing versatility of TBDMS chemistry
Authors: Donga, RA
Chan, TH 
Damha, MJ
Issue Date: 2007
Publisher: National Research Council Canada
Source: Canadian journal of chemistry, 2007, v. 85, no. 4, p. 274-282 How to cite?
Journal: Canadian journal of chemistry 
Abstract: An oligoribonucleotide has been synthesized in solution, using an ionic-liquid-based soluble tag at a scale several hundred times that of a standard solid-phase synthesis approach. Ogilvie's 2′-TBDMS strategy was adopted, and because of the resultant increase in lipophilicity, it allowed an easier purification of the growing oligomer compared with the previously observed for DNA, which does not require 2′ protection. The procedure is illustrated by the synthesis of the pentaribonucleotide sequence AGAUC, corresponding to a segment of the tRNAfMet from E. coli.
URI: http://hdl.handle.net/10397/60778
ISSN: 0008-4042
EISSN: 1480-3291
DOI: 10.1139/v07-022
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