Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/60497
Title: Rethinking the role of ceruloplasmin in brain iron metabolism
Authors: Qian, ZM
Ke, Y
Keywords: Ceruloplasmin
Brain iron metabolism
Iron efflux and influx
Aceruloplasminemia
Neurodegenerative diseases
Issue Date: 2001
Publisher: Elsevier
Source: Brain research reviews, 2001, v. 35, no. 3, p. 287-294 How to cite?
Journal: Brain research reviews 
Abstract: For more than three decades, it has been widely accepted that ceruloplasmin plays an important role in iron efflux from mammalian cells, including brain cells, via the activity of ferroxidase. However, in light of recent findings, this view might not be completely accurate and the role of ceruloplasmin in brain iron metabolism may need to be re-evaluated. Based on recent studies, we propose in this article that the role of ceruloplasmin in iron uptake by brain neuronal cells might be more important than its role in iron release from the cells. A possible explanation of why the absence of ceruloplasmin induces excessive iron accumulation in neurons in aceruloplasminemia (ceruloplasmin gene mutations) was also discussed.
URI: http://hdl.handle.net/10397/60497
ISSN: 0165-0173
DOI: 10.1016/S0165-0173(01)00056-X
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