Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/60496
Title: The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents
Authors: Lam, KH
Gambari, R
Yuen, MCW
Kan, CW 
Chan, P
Xu, JL
Tang, WJ
Chui, CH
Cheng, GYM
Wong, RSM
Lau, FY
Tong, SCW
Chan, AKW
Lai, PBS
Kok, SHL
Cheng, CH
Chan, ASC
Tang, JCO 
Issue Date: 2009
Publisher: Pergamon Press
Source: Bioorganic & medicinal chemistry letters, 2009, v. 19, no. 8, p. 2266-2269 How to cite?
Journal: Bioorganic & medicinal chemistry letters 
Abstract: A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.
URI: http://hdl.handle.net/10397/60496
ISSN: 0960-894X
EISSN: 1464-3405
DOI: 10.1016/j.bmcl.2009.02.091
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