Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/55781
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Yuan, C | - |
dc.creator | Wu, V | - |
dc.creator | Yip, SP | - |
dc.creator | Kwong, DLW | - |
dc.creator | Ying, M | - |
dc.date.accessioned | 2016-09-29T02:18:43Z | - |
dc.date.available | 2016-09-29T02:18:43Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/55781 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2014 Yuan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights | The following publication: Yuan C, Wu VWC, Yip SP, Kwong DLW, Ying M (2014) Predictors of the Extent of Carotid Atherosclerosis in Patients Treated with Radiotherapy for Nasopharyngeal Carcinoma. PLoS ONE 9(12): e116284 is available at https://doi.org/10.1371/journal.pone.0116284 | en_US |
dc.title | Predictors of the extent of Carotid Atherosclerosis in patients treated with radiotherapy for Nasopharyngeal Carcinoma | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 14 | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0116284 | en_US |
dcterms.abstract | Objective: To determine the predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy (RT) for nasopharyngeal carcinoma (NPC). | - |
dcterms.abstract | Methods: The present study investigated 129 post-RT NPC patients. Carotid atherosclerotic parameters, such as carotid intima-media thickness, carotid arterial stiffness and carotid plaque burden (plaque score, the presence of plaque and ≥50% stenosis) were assessed using ultrasonography. The association between carotid atherosclerotic parameters and nine potential predictors, including age, gender, post-RT duration, radiation dose, chemotherapy, diabetes mellitus, hypertension, hypercholesterolemia, and smoking, were determined using multiple regression. The cutoff values of age, post-RT duration and number of cardiovascular risk factors for the presence of carotid plaque or ≥50% carotid stenosis were analyzed using receiver operating characteristic (ROC) curve analysis. Multiple testing was corrected using Benjamini-Hochberg false discovery rate. | - |
dcterms.abstract | Results: Age, post-RT duration and number of cardiovascular risk factors were significantly associated with carotid plaque burden (corrected P value, Pcor<0.05). Age of 44.5 years (sensitivity = 99.2% and specificity = 50%, Pcor<0.01) and post-RT duration of 8.5 years (sensitivity = 75.7% and specificity = 64.3%, Pcor<0.001) were the cutoff values for detecting carotid plaque, while post-RT duration of 13.5 years (sensitivity = 66.7% and specificity = 71.6%, Pcor<0.001) and 1.5 cardiovascular risk factors (sensitivity = 40.7% and specificity = 84.3%, Pcor<0.05) were the cutoff values for screening ≥50% carotid stenosis. | - |
dcterms.abstract | Conclusions: Age, post-RT duration and number of cardiovascular risk factors are significant predictors of carotid atherosclerosis in post-RT NPC patients. Post-RT NPC patients, who are at least 45 years old, with post-RT duration of 9 years or above, and/or have ≥2 cardiovascular risk factors, are more susceptible to carotid atherosclerosis. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 2014, v. 9, no. 12, e116284, p. 1-14 | - |
dcterms.isPartOf | PLoS one | - |
dcterms.issued | 2014 | - |
dc.identifier.pmid | 25551559 | - |
dc.identifier.eissn | 1932-6203 | en_US |
dc.identifier.rosgroupid | 2014001279 | - |
dc.description.ros | 2014-2015 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201810_a bcma | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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Yuan_Predictors_extent_Carotid.PDF | 530.27 kB | Adobe PDF | View/Open |
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