Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/55781
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dc.contributorDepartment of Health Technology and Informatics-
dc.creatorYuan, C-
dc.creatorWu, V-
dc.creatorYip, SP-
dc.creatorKwong, DLW-
dc.creatorYing, M-
dc.date.accessioned2016-09-29T02:18:43Z-
dc.date.available2016-09-29T02:18:43Z-
dc.identifier.urihttp://hdl.handle.net/10397/55781-
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.rights© 2014 Yuan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rightsThe following publication: Yuan C, Wu VWC, Yip SP, Kwong DLW, Ying M (2014) Predictors of the Extent of Carotid Atherosclerosis in Patients Treated with Radiotherapy for Nasopharyngeal Carcinoma. PLoS ONE 9(12): e116284 is available at https://doi.org/10.1371/journal.pone.0116284en_US
dc.titlePredictors of the extent of Carotid Atherosclerosis in patients treated with radiotherapy for Nasopharyngeal Carcinomaen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage14en_US
dc.identifier.volume9en_US
dc.identifier.issue12en_US
dc.identifier.doi10.1371/journal.pone.0116284en_US
dcterms.abstractObjective: To determine the predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy (RT) for nasopharyngeal carcinoma (NPC).-
dcterms.abstractMethods: The present study investigated 129 post-RT NPC patients. Carotid atherosclerotic parameters, such as carotid intima-media thickness, carotid arterial stiffness and carotid plaque burden (plaque score, the presence of plaque and ≥50% stenosis) were assessed using ultrasonography. The association between carotid atherosclerotic parameters and nine potential predictors, including age, gender, post-RT duration, radiation dose, chemotherapy, diabetes mellitus, hypertension, hypercholesterolemia, and smoking, were determined using multiple regression. The cutoff values of age, post-RT duration and number of cardiovascular risk factors for the presence of carotid plaque or ≥50% carotid stenosis were analyzed using receiver operating characteristic (ROC) curve analysis. Multiple testing was corrected using Benjamini-Hochberg false discovery rate.-
dcterms.abstractResults: Age, post-RT duration and number of cardiovascular risk factors were significantly associated with carotid plaque burden (corrected P value, Pcor<0.05). Age of 44.5 years (sensitivity = 99.2% and specificity = 50%, Pcor<0.01) and post-RT duration of 8.5 years (sensitivity = 75.7% and specificity = 64.3%, Pcor<0.001) were the cutoff values for detecting carotid plaque, while post-RT duration of 13.5 years (sensitivity = 66.7% and specificity = 71.6%, Pcor<0.001) and 1.5 cardiovascular risk factors (sensitivity = 40.7% and specificity = 84.3%, Pcor<0.05) were the cutoff values for screening ≥50% carotid stenosis.-
dcterms.abstractConclusions: Age, post-RT duration and number of cardiovascular risk factors are significant predictors of carotid atherosclerosis in post-RT NPC patients. Post-RT NPC patients, who are at least 45 years old, with post-RT duration of 9 years or above, and/or have ≥2 cardiovascular risk factors, are more susceptible to carotid atherosclerosis.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationPLoS one, 2014, v. 9, no. 12, e116284, p. 1-14-
dcterms.isPartOfPLoS one-
dcterms.issued2014-
dc.identifier.pmid25551559-
dc.identifier.eissn1932-6203en_US
dc.identifier.rosgroupid2014001279-
dc.description.ros2014-2015 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validate201810_a bcmaen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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