Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/55728
Title: An in vivo intracellular study of auditory thalamic neurons
Authors: Xiong, Y
Yu, YQ
Fujimoto, K
Chan, YS
He, J
Keywords: Action potential
Current injection
Medial geniculate body
Resting membrane potential
Spontaneous firing
Tuning curve
Issue Date: 2003
Publisher: Cambridge University Press
Source: Thalamus & related systems, 2003, v. 2 , no. 3, p. 253-260 How to cite?
Journal: Thalamus & related systems 
Abstract: The intrinsic electrophysiological properties of medial geniculate body (MGB) neurons and their responses to noise bursts/pure tones were examined in the pentobarbital anesthetized guinea pig through intracellular recording. Discharge rate was calculated in the absence of acoustic stimuli over varied membrane potentials which were changed by intracellular injection of current or through automatic drifting. The non-acoustically-driven firing rate was 45.8±23.3 Hz (mean±S.D., n=8) at membrane potentials of -45 mV, 30.6±19.4 Hz (n=14) at -50 mV, 18.0±12.9 Hz (n=14) at -55 mV, and significantly decreased to 5.7±7.4 Hz at -60 mV, and to 0.7±1.5 Hz (n=10) at -65 mV (ANOVA, P<0.001). The maximum non-acoustically-driven rate observed in the present study was 160 Hz. The auditory responsiveness of the MGB neurons was examined at membrane potentials over a range of -45 to -75 mV: the higher the membrane potential, the greater the responsiveness and vice versa. A putative non-low-threshold calcium spike (non-LTS) burst was observed in the present study. It showed significantly longer inter-spike intervals (11.6±6.0 ms, P<0.001, t -test) than those associated with the putative LTS bursts (6.7±2.4 ms, P<0.001, t-test). The dependence of the temporal structure of the spikes/spike bursts on the stimulus may provide insight into the temporal coding of sound information in the auditory system.
URI: http://hdl.handle.net/10397/55728
ISSN: 1472-9288
EISSN: 1744-8107
DOI: 10.1016/S1472-9288(03)00023-2
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

7
Last Week
0
Last month
Citations as of Sep 26, 2017

Page view(s)

34
Last Week
12
Last month
Checked on Sep 24, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.