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Title: Hydroxyapatite nano-particles coating on the pore surface within poly(DL-lactic-co-glycolic acid) scaffold
Authors: Li, J
Mak, AFT
Keywords: Hydroxyapatite
Poly(DL-lactic-co-glycolic acid)
Tissue engineering
Issue Date: 2007
Publisher: Scientific.Net
Source: Key engineering materials, 2007, v. 334-335 II, p. 1237-1240 How to cite?
Journal: Key engineering materials 
Abstract: This paper describes a novel method for coating hydroxyapatite (HA, Ca 10(PO4)6(OH)2) nano-particles onto poly(DL-lactic-co-glycolic acid) (PLGA) scaffold. Paraffin micro-spheres were used as porogens to create porous scaffolds and as vehicles to transfer HA into PLGA scaffold. HA nano-particles / 50% ethanol suspension was mixed with paraffin micro-spheres. The paraffin micro-spheres / HA suspension were pressed together to form a paraffin scaffold. After it was dried, the HA was coated on the surface of the paraffin spheres. Then, PLGA solution was cast into the inter space among the paraffin micro-spheres and then the solvent was evaporated. Afterwards, the paraffin micro-spheres were dissolved and removed. PLGA scaffolds with controlled pore size, good interconnectivity and high porosity were obtained. The HA nano-particles were transferred from the paraffin surface to the surface of the pore wall throughout the PLGA scaffold.
ISSN: 1013-9826
EISSN: 1662-9795
Appears in Collections:Conference Paper

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