Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/5076
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dc.contributorDepartment of Applied Physics-
dc.creatorLei, ZQ-
dc.creatorLi, L-
dc.creatorLi, GJ-
dc.creatorLeung, CW-
dc.creatorShi, J-
dc.creatorWong, CM-
dc.creatorLo, KC-
dc.creatorChan, WK-
dc.creatorMak, CSK-
dc.creatorChan, SB-
dc.creatorChan, NMM-
dc.creatorLeung, CH-
dc.creatorLai, PT-
dc.creatorPong, PWT-
dc.date.accessioned2014-12-11T08:22:40Z-
dc.date.available2014-12-11T08:22:40Z-
dc.identifier.issn0021-8979-
dc.identifier.urihttp://hdl.handle.net/10397/5076-
dc.language.isoenen_US
dc.publisherAmerican Institute of Physicsen_US
dc.rights© 2012 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Z. Q. Lei et al., J. Appl. Phys. 111, 07E505 (2012) and may be found at http://link.aip.org/link/?jap/111/07E505.en_US
dc.subjectBiosensorsen_US
dc.subjectCanceren_US
dc.subjectLiveren_US
dc.subjectMagnesium compoundsen_US
dc.subjectMagnetic particlesen_US
dc.subjectNanomedicineen_US
dc.subjectNanoparticlesen_US
dc.subjectProteinsen_US
dc.subjectTumoursen_US
dc.subjectTunnelling magnetoresistanceen_US
dc.titleLiver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensorsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1-
dc.identifier.epage3-
dc.identifier.volume111-
dc.identifier.issue7-
dc.identifier.doi10.1063/1.3676212-
dcterms.abstractWe have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm² possess tunneling magnetoresistance (TMR) of 122% and sensitivity of 0.95%/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of applied physics, 1 Apr. 2012, v. 111, no. 7, 07E505, p. 1-3-
dcterms.isPartOfJournal of applied physics-
dcterms.issued2012-04-01-
dc.identifier.isiWOS:000303282401318-
dc.identifier.scopus2-s2.0-84861728395-
dc.identifier.eissn1089-7550-
dc.identifier.rosgroupidr60152-
dc.description.ros2011-2012 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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