Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/4705
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.contributor | School of Optometry | - |
dc.creator | Leung, KH | en_US |
dc.creator | Yiu, WC | en_US |
dc.creator | Yap, KHM | en_US |
dc.creator | Ng, PW | en_US |
dc.creator | Fung, WY | en_US |
dc.creator | Sham, PC | en_US |
dc.creator | Yip, SP | en_US |
dc.date.accessioned | 2014-12-11T08:25:08Z | - |
dc.date.available | 2014-12-11T08:25:08Z | - |
dc.identifier.issn | 0146-0404 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/4705 | - |
dc.language.iso | en | en_US |
dc.publisher | Association for Research in Vision and Ophthalmology | en_US |
dc.rights | ©2011 Association for Research in Vision and Ophthalmology. This is a postprint of an article whose final and definitive form has been published in the IOVS. | en_US |
dc.subject | Matrix metalloproteinase 2/genetics | en_US |
dc.subject | Genetic predisposition to disease | en_US |
dc.subject | Myopia, degenerative/genetics | en_US |
dc.subject | Polymorphism, single nucleotide | en_US |
dc.subject | Sequence analysis, DNA/methods | en_US |
dc.subject | Tissue inhibitor of metalloproteinase-2/genetics | en_US |
dc.subject | Tissue inhibitor of metalloproteinase-3/genetics | en_US |
dc.title | Systematic investigation of the relationship between high myopia and polymorphisms of the MMP₂, TIMP₂, and TIMP₃ genes by a DNA pooling approach | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.description.otherinformation | Author name used in this manuscript: Maurice K. H. Yap | en_US |
dc.identifier.spage | 3893 | en_US |
dc.identifier.epage | 3900 | en_US |
dc.identifier.volume | 52 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.doi | 10.1167/iovs.11-7286 | en_US |
dcterms.abstract | Purpose. This study examined the relationship between high myopia and three myopia candidate genes—matrix metalloproteinase 2 (MMP2) and tissue inhibitor of metalloproteinase-2 and -3 (TIMP2 and TIMP3)—involved in scleral remodeling. | - |
dcterms.abstract | Methods. Recruited for the study were unrelated adult Han Chinese who were high myopes (spherical equivalent, ≤ −6.0 D in both eyes; cases) and emmetropes (within ±1.0 D in both eyes; controls). Sample set 1 had 300 cases and 300 controls, and sample set 2 had 356 cases and 354 controls. Forty-nine tag single-nucleotide polymorphisms (SNPs) were selected from these candidate genes. The first stage was an initial screen of six case pools and six control pools constructed from sample set 1, each pool consisting of 50 distinct subjects of the same affection status. In the second stage, positive SNPs from the first stage were confirmed by genotyping individual samples forming the DNA pools. In the third stage, positive SNPs from stage 2 were replicated, with sample set 2 genotyped individually. | - |
dcterms.abstract | Results. Of the 49 SNPs screened by DNA pooling, three passed the lenient threshold of P < 0.10 (nested ANOVA) and were followed up by individual genotyping. Of the three SNPs genotyped, two TIMP3 SNPs were found to be significantly associated with high myopia by single-marker or haplotype analysis. However, the initial positive results could not be replicated by sample set 2. | - |
dcterms.abstract | Conclusions. MMP2, TIPM2, and TIMP3 genes were not associated with high myopia in this Chinese sample and hence are unlikely to play a major role in the genetic susceptibility to high myopia. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Investigative ophthalmology and visual science, 31 May 2011, v. 52, no. 6, p. 3893-3900 | en_US |
dcterms.isPartOf | Investigative ophthalmology and visual science | en_US |
dcterms.issued | 2011-05-31 | - |
dc.identifier.isi | WOS:000293335400062 | - |
dc.identifier.scopus | 2-s2.0-80051763988 | - |
dc.identifier.eissn | 1552-5783 | en_US |
dc.identifier.rosgroupid | r54709 | - |
dc.description.ros | 2010-2011 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA, SO-0103 | - |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 61118593 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IOVS-11-7286_MS-PolyUIR.pdf | Pre-published version | 354.07 kB | Adobe PDF | View/Open |
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