Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/44197
Title: Sickness : from the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons
Authors: Poon, DCH
Ho, YS 
Chiu, K
Wong, HL
Chang, RCC
Keywords: Complement factors
Cytokines
Depression
Neurohormones
Neuroinflammation
Prostaglandins
Sickness response
Systemic inflammation
Issue Date: 2015
Publisher: Pergamon
Source: Neuroscience & biobehavioral reviews, 2015, v. 57, p. 30-45 How to cite?
Journal: Neuroscience & biobehavioral reviews 
Abstract: Systemic inflammation leads to a variety of physiological (e.g. fever) and behavioral (e.g. anorexia, immobility, social withdrawal, depressed mood, disturbed sleep) responses that are collectively known as sickness. While these phenomena have been studied for the past few decades, the neurobiological mechanisms by which sickness occurs remain unclear. In this review, we first revisit how the body senses and responds to infections and injuries by eliciting systemic inflammation. Next, we focus on how peripheral inflammatory molecules such as cytokines, prostaglandins, and activated complement factors communicate with the brain to trigger neuroinflammation and sickness. Since depression also involves inflammation, we further elaborate on the interrelationship between sickness and depression. Finally, we discuss how immune activation can modulate neurons in the brain, and suggest future perspectives to help unravel how changes in neuronal functions relate to sickness responses.
URI: http://hdl.handle.net/10397/44197
ISSN: 0149-7634
DOI: 10.1016/j.neubiorev.2015.07.015
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