Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/44018
Title: Antimicrobial and toxicological evaluations of binuclear mercury(ii)bis(alkynyl) complexes containing oligothiophenes and bithiazoles
Authors: Lam, PL
Lu, GL
Choi, KH
Lin, Z
Kok, SHL
Lee, KKH
Lam, KH
Li, H
Gambari, R
Bian, ZX
Wong, WY
Chui, CH
Issue Date: 2016
Publisher: Royal Society of Chemistry
Source: RSC advances, 2016, v. 6, no. 20, p. 16736-16744 How to cite?
Journal: RSC advances 
Abstract: Metals and metal complexes are promising antimicrobials due to their powerful inhibitory activity against microbes. However, the potential for metal toxicity to life remains unsolved. Mercury is a toxic element with no known positive biological functions, and its toxicity to humans is well known. With the known toxicity of Hg and its complexes, their usefulness for antimicrobial therapy should not be neglected. In this work, we investigated the antimicrobial activity of bis-(alkynyl)mercury(ii) complexes with oligothiophene and bithiazole linking units against MRSA and C. albicans (pathogens commonly co-inhabit infected sites), and their cytotoxicity was tested on NIH 3T3 cells. Among the Hg(ii) complexes, complex 2 showed potent microcidal activity against MRSA (MIC and MBC values = 0.2 μg mL-1) and C. albicans (MIC and MBC values = 0.4 μg mL-1). Complex 2 displayed a highly distinguished zone of clearance with comparably sharp zone edges on microbial agar plates. Time-kill kinetic studies showed that MRSA colonies were reduced by approximately 5 logs during the initial 3 h exposure to complex 2 at an 8× MIC level. The possible antimicrobial mechanism might be due to the intracellular ROS generation by complex 2 that caused the loss in MRSA viability. Complex 2 exhibited a higher IC50 value (0.8 μg mL-1) towards NIH 3T3 cells that was greater than its corresponding MIC values against tested microbes. Hg(ii) complexes would be potent antimicrobials, but a challenge is to fully utilize their potential inhibitory effects on microbes while lowering their toxic levels on human health.
URI: http://hdl.handle.net/10397/44018
EISSN: 2046-2069
DOI: 10.1039/c5ra27600d
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

5
Last Week
0
Last month
Citations as of Sep 9, 2017

WEB OF SCIENCETM
Citations

5
Last Week
0
Last month
Citations as of Sep 16, 2017

Page view(s)

30
Last Week
2
Last month
Checked on Sep 18, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.