Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43957
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorDepartment of Rehabilitation Sciencesen_US
dc.creatorLam, FMHen_US
dc.creatorBui, Men_US
dc.creatorYang, FZHen_US
dc.creatorPang, MYCen_US
dc.date.accessioned2016-06-07T06:37:28Z-
dc.date.available2016-06-07T06:37:28Z-
dc.identifier.issn0937-941X (print)en_US
dc.identifier.urihttp://hdl.handle.net/10397/43957-
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rights© International Osteoporosis Foundation and National Osteoporosis Foundation 2015en_US
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in Osteoporosis International. The final authenticated version is available online at: https://doi.org/10.1007/s00198-015-3307-7en_US
dc.subjectBoneen_US
dc.subjectCerebrovascular accidenten_US
dc.subjectComputed tomographyen_US
dc.subjectOsteoporosisen_US
dc.titleChronic effects of stroke on hip bone density and tibial morphology : a longitudinal studyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage591en_US
dc.identifier.epage603en_US
dc.identifier.volume27en_US
dc.identifier.issue2en_US
dc.identifier.doi10.1007/s00198-015-3307-7en_US
dcterms.abstractSummary: The study aimed to quantify the long-term effects of stroke on tibial bone morphology and hip bone density. Only the trabecular bone mineral density and bone strength index in the hemiparetic tibial distal epiphysis showed a significant decline among individuals who had sustained a stroke 12–24 months ago. Introduction: This study aims to determine the changes in bone density and morphology in lower limb long bones during a 1-year follow-up period and their relationship to muscle function in chronic stroke patients. Methods: Twenty-eight chronic stroke patients (12–166 months after the acute stroke event at initial assessment) and 27 controls underwent bilateral scanning of the hip and tibia using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, respectively. Each subject was re-assessed 1 year after the initial assessment. Results: Twenty stroke cases and 23 controls completed all assessments. At the end of the follow-up, the paretic tibial distal epiphysis suffered significant decline in trabecular bone density (−1.8 ± 0.6 %, p = 0.006) and bone strength index (−2.7 ± 0.6 %, p < 0.001). More severe decline in the former was associated with poorer leg muscle strength (ρ = 0.447, p = 0.048) and motor recovery (ρ = 0.489, p = 0.029) measured at initial assessment. The loss in trabecular bone density remained significant among those whose stroke onset was 12–24 months ago (p < 0.001), but not among those whose stroke onset was beyond 24 months ago (p > 0.05) at the time of initial assessment. The changes of outcomes in the tibial diaphysis, except for cortical bone mineral content on the non-paretic side (−1.3 ± 0.3 %, p = 0.003), and hip bone density were well within the margin of error for precision. Conclusions: There is evidence of continuous trabecular bone loss in the paretic tibial distal epiphysis among chronic stroke patients, but it tends to plateau after 2 years of stroke onset. The steady state may have been reached earlier in the hip and tibial diaphysis.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationOsteoporosis international, Feb. 2016, v. 27, no. 2, p. 591-603en_US
dcterms.isPartOfOsteoporosis internationalen_US
dcterms.issued2016-02-
dc.identifier.isiWOS:000370046200018-
dc.identifier.scopus2-s2.0-84957442957-
dc.identifier.rosgroupid2015001543-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journalen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera0590-n13-
dc.identifier.SubFormID337-
dc.description.fundingSourceRGCen_US
dc.description.fundingTextP0003963en_US
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
a0590-n13_Prospective_bone_v_13.pdfPre-Published version403.34 kBAdobe PDFView/Open
Open Access Information
Status open access
File Version Final Accepted Manuscript
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

119
Last Week
0
Last month
Citations as of Mar 24, 2024

Downloads

90
Citations as of Mar 24, 2024

SCOPUSTM   
Citations

20
Last Week
0
Last month
Citations as of Mar 28, 2024

WEB OF SCIENCETM
Citations

15
Last Week
0
Last month
Citations as of Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.