Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/43957
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | en_US |
dc.creator | Lam, FMH | en_US |
dc.creator | Bui, M | en_US |
dc.creator | Yang, FZH | en_US |
dc.creator | Pang, MYC | en_US |
dc.date.accessioned | 2016-06-07T06:37:28Z | - |
dc.date.available | 2016-06-07T06:37:28Z | - |
dc.identifier.issn | 0937-941X (print) | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/43957 | - |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.rights | © International Osteoporosis Foundation and National Osteoporosis Foundation 2015 | en_US |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in Osteoporosis International. The final authenticated version is available online at: https://doi.org/10.1007/s00198-015-3307-7 | en_US |
dc.subject | Bone | en_US |
dc.subject | Cerebrovascular accident | en_US |
dc.subject | Computed tomography | en_US |
dc.subject | Osteoporosis | en_US |
dc.title | Chronic effects of stroke on hip bone density and tibial morphology : a longitudinal study | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 591 | en_US |
dc.identifier.epage | 603 | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.doi | 10.1007/s00198-015-3307-7 | en_US |
dcterms.abstract | Summary: The study aimed to quantify the long-term effects of stroke on tibial bone morphology and hip bone density. Only the trabecular bone mineral density and bone strength index in the hemiparetic tibial distal epiphysis showed a significant decline among individuals who had sustained a stroke 12–24 months ago. Introduction: This study aims to determine the changes in bone density and morphology in lower limb long bones during a 1-year follow-up period and their relationship to muscle function in chronic stroke patients. Methods: Twenty-eight chronic stroke patients (12–166 months after the acute stroke event at initial assessment) and 27 controls underwent bilateral scanning of the hip and tibia using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, respectively. Each subject was re-assessed 1 year after the initial assessment. Results: Twenty stroke cases and 23 controls completed all assessments. At the end of the follow-up, the paretic tibial distal epiphysis suffered significant decline in trabecular bone density (−1.8 ± 0.6 %, p = 0.006) and bone strength index (−2.7 ± 0.6 %, p < 0.001). More severe decline in the former was associated with poorer leg muscle strength (ρ = 0.447, p = 0.048) and motor recovery (ρ = 0.489, p = 0.029) measured at initial assessment. The loss in trabecular bone density remained significant among those whose stroke onset was 12–24 months ago (p < 0.001), but not among those whose stroke onset was beyond 24 months ago (p > 0.05) at the time of initial assessment. The changes of outcomes in the tibial diaphysis, except for cortical bone mineral content on the non-paretic side (−1.3 ± 0.3 %, p = 0.003), and hip bone density were well within the margin of error for precision. Conclusions: There is evidence of continuous trabecular bone loss in the paretic tibial distal epiphysis among chronic stroke patients, but it tends to plateau after 2 years of stroke onset. The steady state may have been reached earlier in the hip and tibial diaphysis. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Osteoporosis international, Feb. 2016, v. 27, no. 2, p. 591-603 | en_US |
dcterms.isPartOf | Osteoporosis international | en_US |
dcterms.issued | 2016-02 | - |
dc.identifier.isi | WOS:000370046200018 | - |
dc.identifier.scopus | 2-s2.0-84957442957 | - |
dc.identifier.rosgroupid | 2015001543 | - |
dc.description.ros | 2015-2016 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | a0590-n13 | - |
dc.identifier.SubFormID | 337 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingText | P0003963 | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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a0590-n13_Prospective_bone_v_13.pdf | Pre-Published version | 403.34 kB | Adobe PDF | View/Open |
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