Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43955
Title: Design of an indolylphosphine ligand for reductive elimination-demanding monoarylation of acetone using aryl chlorides
Authors: Fu, WC
So, CM
Chow, WK
Yuen, OY
Kwong, FY 
Issue Date: 2015
Publisher: American Chemical Society
Source: Organic letters, 2015, v. 17, no. 18, p. 4612-4615 How to cite?
Journal: Organic letters 
Abstract: The rational design of a phosphine ligand for the reductive elimination-demanding Pd-catalyzed mono-α-arylation of acetone is demonstrated and reported. The catalyst is tolerant of previously proven challenging electron-deficient aryl chlorides and provides excellent product yields with down to 0.1 mol % Pd. Preliminary investigations suggest that the rate-limiting step for the proposed system is the oxidative addition of aryl chlorides, in which it contradicts previous findings regarding the α-arylation of acetone with aryl halides.
URI: http://hdl.handle.net/10397/43955
ISSN: 1523-7060
EISSN: 1523-7052
DOI: 10.1021/acs.orglett.5b02344
Appears in Collections:Journal/Magazine Article

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