Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43924
Title: Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells
Authors: Wang, H
Lau, BWM 
Wang, NL
Wang, SY
Lu, QJ
Chang, RCC
So, KF
Keywords: Adult
Lycium barbarum (wolfberry)
Lycium barbarum polysaccharides
Nerve regeneration
Neural regeneration
Neurogenesis
Retinal disease
Traditional Chinese medicine
Issue Date: 2015
Publisher: Medknow Publications and Media Pvt Ltd
Source: Neural regeneration research, 2015, v. 10, no. 12, p. 1976-1981 How to cite?
Journal: Neural regeneration research 
Abstract: Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low- and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.
URI: http://hdl.handle.net/10397/43924
ISSN: 1673-5374
DOI: 10.4103/1673-5374.172315
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

3
Last Week
0
Last month
Citations as of Oct 12, 2017

WEB OF SCIENCETM
Citations

2
Last Week
0
Last month
Citations as of Oct 18, 2017

Page view(s)

40
Last Week
2
Last month
Checked on Oct 16, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.