Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43878
Title: Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2
Authors: Xie, M
Li, Y 
Zhao, Z
Chen, A
Li, J
Li, Z
Li, G
Lin, X
Keywords: Curcumin
Drug delivery system
Silk fibroin
Supercritical CO2
Issue Date: 2016
Publisher: North-Holland
Source: Materials letters, 2016, v. 167, p. 175-178 How to cite?
Journal: Materials letters 
Abstract: A silk fibroin (SF)-derived nanofibrous drug delivery system was fabricated by solution-enhanced dispersion via supercritical CO2 (SEDS) (20 MPa pressure, 8 mL/min flow rate, 35 °C temperature) in this study. Curcumin (CM) was used as a water-insoluble drug model. Nanofibrous structure with controllable fiber diameter (<100 nm) was obtained, and inter-molecular hydrogen bonds were formed between CM and SF; the crystallinity of the incorporated CM was remarkably decreased, which led to a significant enhancement in solubility of incorporated CM. In conclusion, SEDS could be developed to fabricate polymeric nanofibrous drug delivery system.
URI: http://hdl.handle.net/10397/43878
ISSN: 0167-577X
DOI: 10.1016/j.matlet.2015.12.151
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