Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43804
Title: Construction of vicinal tetrasubstituted stereocenters with a C-F bond through a catalytic enantioselective detrifluoroacetylative mannich reaction
Authors: Liu, X
Zhang, J
Zhao, L
Ma, S
Yang, D
Yan, W
Wang, R
Issue Date: 2015
Publisher: American Chemical Society
Source: Journal of organic chemistry, 2015, v. 80, no. 24, p. 12651-12658 How to cite?
Journal: Journal of organic chemistry 
Abstract: An efficient asymmetric detrifluoroacetylative Mannich reaction of 2-fluoro-1,3-diketones/hydrates with isatin-derived ketimines catalyzed by a chiral copper(II)-diamine complex has been realized. The reaction afforded a series of 3-substituted 3-amino-2-oxindoles bearing fluorine-containing vicinal tetrasubstituted stereocenters in high yields (up to 99%) with excellent diastereoselectivities (up to >20:1 dr) and enantioselectivities (up to 94% ee).
URI: http://hdl.handle.net/10397/43804
ISSN: 0022-3263
EISSN: 1520-6904
DOI: 10.1021/acs.joc.5b02238
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