Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/43799
DC Field | Value | Language |
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dc.contributor | Department of Rehabilitation Sciences | - |
dc.creator | Li, Y | - |
dc.creator | Alam, M | - |
dc.creator | Guo, S | - |
dc.creator | Ting, K | - |
dc.creator | He, J | - |
dc.date.accessioned | 2016-06-07T06:23:20Z | - |
dc.date.available | 2016-06-07T06:23:20Z | - |
dc.identifier.issn | 1743-0003 | - |
dc.identifier.uri | http://hdl.handle.net/10397/43799 | - |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central | en_US |
dc.rights | © 2014 Li et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | en_US |
dc.rights | The following publication Li, Y., Alam, M., Guo, S., Ting, K., & He, J. (2014). Electronic bypass of spinal lesions : activation of lower motor neurons directly driven by cortical neural signals. Journal of Neuroengineering and Rehabilitation, 11, 107, 1-12 is available at https://dx.doi.org/10.1186/1743-0003-11-107 | en_US |
dc.subject | Extracellular recording | en_US |
dc.subject | Functional electrical stimulation | en_US |
dc.subject | Intracortical microstimulation | en_US |
dc.subject | Intraspinal microstimulation | en_US |
dc.subject | Locomotion | en_US |
dc.subject | Multielectrode array | en_US |
dc.subject | Neural spikes | en_US |
dc.subject | Neuromotor prostheses | en_US |
dc.subject | Spinal cord injury | en_US |
dc.title | Electronic bypass of spinal lesions : activation of lower motor neurons directly driven by cortical neural signals | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.epage | 12 | - |
dc.identifier.volume | 11 | - |
dc.identifier.doi | 10.1186/1743-0003-11-107 | - |
dcterms.abstract | Background: Lower motor neurons in the spinal cord lose supraspinal inputs after complete spinal cord injury, leading to a loss of volitional control below the injury site. Extensive locomotor training with spinal cord stimulation can restore locomotion function after spinal cord injury in humans and animals. However, this locomotion is non-voluntary, meaning that subjects cannot control stimulation via their natural "intent". A recent study demonstrated an advanced system that triggers a stimulator using forelimb stepping electromyographic patterns to restore quadrupedal walking in rats with spinal cord transection. However, this indirect source of "intent" may mean that other non-stepping forelimb activities may false-trigger the spinal stimulator and thus produce unwanted hindlimb movements. Methods. We hypothesized that there are distinguishable neural activities in the primary motor cortex during treadmill walking, even after low-thoracic spinal transection in adult guinea pigs. We developed an electronic spinal bridge, called "Motolink", which detects these neural patterns and triggers a "spinal" stimulator for hindlimb movement. This hardware can be head-mounted or carried in a backpack. Neural data were processed in real-time and transmitted to a computer for analysis by an embedded processor. Off-line neural spike analysis was conducted to calculate and preset the spike threshold for "Motolink" hardware. Results: We identified correlated activities of primary motor cortex neurons during treadmill walking of guinea pigs with spinal cord transection. These neural activities were used to predict the kinematic states of the animals. The appropriate selection of spike threshold value enabled the "Motolink" system to detect the neural "intent" of walking, which triggered electrical stimulation of the spinal cord and induced stepping-like hindlimb movements. Conclusion: We present a direct cortical "intent"-driven electronic spinal bridge to restore hindlimb locomotion after complete spinal cord injury. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of neuroengineering and rehabilitation, 2014, v. 11, 107, p. 1-12 | - |
dcterms.isPartOf | Journal of neuroEngineering and rehabilitation | - |
dcterms.issued | 2014 | - |
dc.identifier.scopus | 2-s2.0-84940277035 | - |
dc.identifier.pmid | 24990580 | - |
dc.identifier.artn | 107 | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Li_Electronic_Bypass_Spinal.pdf | 2.68 MB | Adobe PDF | View/Open |
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