Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43710
Title: The toxic effects of indoor atmospheric fine particulate matter collected from allergic and non-allergic families in Wuhan on mouse peritoneal macrophages
Authors: Yan, B
Li, J
Guo, J
Ma, P
Wu, Z
Ling, Z
Guo, H 
Hiroshi, Y
Yanagi, U
Yang, X
Zhu, S
Chen, M
Keywords: Allergy
Cytokines
Macrophages
Oxidative stress
PM2.5
Issue Date: 2016
Publisher: John Wiley & Sons
Source: Journal of applied toxicology, 2016, v. 36, no. 4, p. 596-608 How to cite?
Journal: Journal of applied toxicology 
Abstract: Recent studies have shown that fine particulate matter (PM2.5) is associated with multiple adverse health outcomes and PM2.5-induced oxidative stress is now commonly known as a proposed mechanism of PM2.5-mediated toxicity. However, the association between allergic symptoms in children and exposure to PM2.5 has not been fully elucidated, particularly the role of PM2.5 on the indoor environment involved in allergy or non-allergy is unknown. The aim of the present study was to explore whether indoor PM2.5 from the homes of children with allergic symptoms had more increased risks of allergy than that of healthy ones and then compare the toxicity and inflammatory response of them. In this study, indoor PM2.5 was collected from the homes of schoolchildren with allergic symptoms and those of healthy ones respectively, and components of PM2.5 were analyzed. PM2.5-mediated oxidative damage and inflammatory response were further evaluated in mouse peritoneal macrophages based on its effects on the levels of reactive oxygen species accumulation, lipid peroxidation, DNA damage or cytokine production. It seems that oxidative stress may contribute to PM2.5-induced toxicity, and PM2.5 from the allergic indoor environment produced more serious toxic effects and an inflammatory response on mouse peritoneal macrophages than that from a non-allergic indoor environment.
URI: http://hdl.handle.net/10397/43710
ISSN: 0260-437X
DOI: 10.1002/jat.3217
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