Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43668
Title: Nano-curcumin prepared via supercritical : improved anti-bacterial, anti-oxidant and anti-cancer efficacy
Authors: Xie, M
Fan, D
Zhao, Z
Li, Z
Li, G
Chen, Y
He, X
Chen, A
Li, J
Lin, X
Zhi, M
Li, Y 
Lan, P
Keywords: Anti-bacterial
Anti-cancer
Anti-oxidant
Curcumin
Supercritical CO2
Issue Date: 2015
Publisher: Elsevier
Source: International journal of pharmaceutics, 2015, v. 496, no. 2, p. 732-740 How to cite?
Journal: International journal of pharmaceutics 
Abstract: Curcumin (CM) possesses multiple biological activities. However, poor water solubility and low bioavailability limit its application in biomedical fields. CM nanoparticles (NPs) (230-240 nm) were prepared by solution-enhanced dispersion via supercritical CO2 (SEDS) (22-22.5 MPa pressure, 31-32.5 °C temperature) and its biological functions were evaluated in this study. The Minimum inhibitory concentration of CM NPs against S. aureus (∼250 μg/mL) was lower than CM-DMSO (∼500 μg/mL). Meanwhile, CM NPs showed effective anti-oxidant ability at a concentration raging from 125 to 2000 μg/mL. CM NPs showed time-dependent intracellular internalization ability, resulting in an enhanced anti-cancer effect on colorectal cancer cells (HCT116), and the mechanism could be explained by cell cycle arrest in G2/M phase associated with inducing apoptotic cells. Moreover, CM NPs exhibited reduced cytotoxicity on normal cells (NCM460) compared to CM-DMSO and 5-Fu. In conclusion, CM NPs prepared via SEDS showed potentials in biomedical applications.
URI: http://hdl.handle.net/10397/43668
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2015.11.016
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