Please use this identifier to cite or link to this item:
Title: Concise synthesis and antidiabetic effect of three natural triterpenoid saponins isolated from Fadogia ancylantha (Makoni tea)
Authors: Feng, ZL
Wu, SP
Li, WH
Guo, TT
Liu, QC
Keywords: Bidesmosidic oleanolic acid saponins
Issue Date: 2015
Publisher: Wiley-Blackwell
Source: Helvetica chimica acta, 2015, v. 98, no. 9, p. 1254-1266 How to cite?
Journal: Helvetica chimica acta 
Abstract: The first concise synthesis of the bidesmosidic oleanolic acid saponins 1-3 isolated from Fadogia ancylantha (Makoni tea) have been accomplished through a 'one-pot sequential glycosylation' strategy with two glycosyl 1-(trichloroacetimidate)s as glycosyl donors. The synthesized natural products 1-3 were then evaluated for their inhibitory activities against α-glucosidase, α-amylase, and lipase. Among the assayed compounds 1-3, compound 1 showed strong α-glucosidase and α-amylase inhibition, with IC<inf>50</inf> values of 160 and 180 μM, respectively. Moreover, compounds 2 and 3 showed strong inhibition against α-glucosidase and lipase, with the respective IC<inf>50</inf> values of 170 and 190 μM, and 190 and 200 μM.
ISSN: 0018-019X
DOI: 10.1002/hlca.201500061
Appears in Collections:Journal/Magazine Article

View full-text via PolyU eLinks SFX Query
Show full item record

Page view(s)

Last Week
Last month
Checked on Aug 20, 2017

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.