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Title: Concise synthesis and antidiabetic effect of three natural triterpenoid saponins isolated from Fadogia ancylantha (Makoni tea)
Authors: Feng, ZL
Wu, SP
Li, WH
Guo, TT
Liu, QC
Keywords: Bidesmosidic oleanolic acid saponins
Issue Date: 2015
Publisher: Wiley-Blackwell
Source: Helvetica chimica acta, 2015, v. 98, no. 9, p. 1254-1266 How to cite?
Journal: Helvetica chimica acta 
Abstract: The first concise synthesis of the bidesmosidic oleanolic acid saponins 1-3 isolated from Fadogia ancylantha (Makoni tea) have been accomplished through a 'one-pot sequential glycosylation' strategy with two glycosyl 1-(trichloroacetimidate)s as glycosyl donors. The synthesized natural products 1-3 were then evaluated for their inhibitory activities against α-glucosidase, α-amylase, and lipase. Among the assayed compounds 1-3, compound 1 showed strong α-glucosidase and α-amylase inhibition, with IC<inf>50</inf> values of 160 and 180 μM, respectively. Moreover, compounds 2 and 3 showed strong inhibition against α-glucosidase and lipase, with the respective IC<inf>50</inf> values of 170 and 190 μM, and 190 and 200 μM.
ISSN: 0018-019X
DOI: 10.1002/hlca.201500061
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