Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/43548
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.contributor | Department of Biomedical Engineering | - |
dc.creator | Sin, TK | - |
dc.creator | Yung, BY | - |
dc.creator | Yip, SP | - |
dc.creator | Chan, LW | - |
dc.creator | Wong, CS | - |
dc.creator | Tam, EW | - |
dc.creator | Siu, PM | - |
dc.date.accessioned | 2016-06-07T06:16:40Z | - |
dc.date.available | 2016-06-07T06:16:40Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/43548 | - |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Research Foundation | en_US |
dc.rights | Copyright © 2015 Sin, Yung, Yip, Chan, Wong, Tam and Siu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_US |
dc.rights | The following publication Sin TK, Yung BY, Yip SP, Chan LW, Wong CS, Tam EW and Siu PM (2015) SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression. Front. Physiol. 6:293,1-10 is available at https://dx.doi.org/10.3389/fphys.2015.00293 | en_US |
dc.subject | Compression injury | en_US |
dc.subject | Pressure ulcer | en_US |
dc.subject | Resveratrol | en_US |
dc.subject | SIRT1 | en_US |
dc.subject | Skeletal muscle | en_US |
dc.title | SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 10 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.doi | 10.3389/fphys.2015.00293 | en_US |
dcterms.abstract | Our current understanding on the molecular mechanisms by which sustained compression induces skeletal muscle injury is very limited. This study aimed to test the hypothesis that activation of SIRT1 by the natural antioxidant resveratrol could deactivate apoptotic and catabolic signaling in skeletal muscle exposed to moderate compression. Two cycles of 6-h constant pressure at 100 mmHg was applied to the tibialis region of right, but not left hindlimbs of Sprague Dawley rats pre-treated with DMSO (vehicle control) or resveratrol with/without sirtinol. Skeletal muscle tissues lying underneath and spatially corresponding to the compressed sites were collected for analyses. Resveratrol prevented the compression-induced manifestations of pathohistological damages including elevations of the number of interstitial nuclei and area of interstitial space and ameliorated oxidative damages measured as 4-hydroxy-2-nonenal (4HNE) and nitrotyrosine in skeletal muscle. In parallel, resveratrol augmented the expression level and activity of SIRT1 and phosphorylation levels of Foxo3a and Akt while suppressed the increases in protein abundances of p53, Bax, MAFbx, and ubiquitin, enzymatic activities of caspase 3 and 20S proteasome, and apoptotic DNA fragmentation in the compressed muscle. These favorable myoprotective effects of resveratrol were diminished upon pharmacological blockade of SIRT1 by using sirtinol. These novel data support the hypothesis that the anti-apoptotic and anti-catabolic effects of resveratrol on compression injury in skeletal muscle required the action of SIRT1. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Frontiers in physiology, 21 Oct. 2015, v. 6, 293, p. 1-10 | - |
dcterms.isPartOf | Frontiers in physiology | - |
dcterms.issued | 2015-10-21 | - |
dc.identifier.isi | WOS:000366737800001 | - |
dc.identifier.scopus | 2-s2.0-84946575216 | - |
dc.identifier.eissn | 1664-042X | en_US |
dc.identifier.artn | 293 | en_US |
dc.identifier.rosgroupid | 2015001627 | - |
dc.description.ros | 2015-2016 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Sin_SIRT1-dependent_Myoprotective_Resveratrol.pdf | 1.83 MB | Adobe PDF | View/Open |
Page views
130
Last Week
0
0
Last month
Citations as of Mar 24, 2024
Downloads
73
Citations as of Mar 24, 2024
SCOPUSTM
Citations
19
Last Week
0
0
Last month
Citations as of Mar 28, 2024
WEB OF SCIENCETM
Citations
19
Last Week
0
0
Last month
Citations as of Mar 28, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.