Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43548
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dc.contributorDepartment of Health Technology and Informatics-
dc.contributorDepartment of Biomedical Engineering-
dc.creatorSin, TK-
dc.creatorYung, BY-
dc.creatorYip, SP-
dc.creatorChan, LW-
dc.creatorWong, CS-
dc.creatorTam, EW-
dc.creatorSiu, PM-
dc.date.accessioned2016-06-07T06:16:40Z-
dc.date.available2016-06-07T06:16:40Z-
dc.identifier.urihttp://hdl.handle.net/10397/43548-
dc.language.isoenen_US
dc.publisherFrontiers Research Foundationen_US
dc.rightsCopyright © 2015 Sin, Yung, Yip, Chan, Wong, Tam and Siu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rightsThe following publication Sin TK, Yung BY, Yip SP, Chan LW, Wong CS, Tam EW and Siu PM (2015) SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression. Front. Physiol. 6:293,1-10 is available at https://dx.doi.org/10.3389/fphys.2015.00293en_US
dc.subjectCompression injuryen_US
dc.subjectPressure ulceren_US
dc.subjectResveratrolen_US
dc.subjectSIRT1en_US
dc.subjectSkeletal muscleen_US
dc.titleSIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compressionen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage10en_US
dc.identifier.volume6en_US
dc.identifier.doi10.3389/fphys.2015.00293en_US
dcterms.abstractOur current understanding on the molecular mechanisms by which sustained compression induces skeletal muscle injury is very limited. This study aimed to test the hypothesis that activation of SIRT1 by the natural antioxidant resveratrol could deactivate apoptotic and catabolic signaling in skeletal muscle exposed to moderate compression. Two cycles of 6-h constant pressure at 100 mmHg was applied to the tibialis region of right, but not left hindlimbs of Sprague Dawley rats pre-treated with DMSO (vehicle control) or resveratrol with/without sirtinol. Skeletal muscle tissues lying underneath and spatially corresponding to the compressed sites were collected for analyses. Resveratrol prevented the compression-induced manifestations of pathohistological damages including elevations of the number of interstitial nuclei and area of interstitial space and ameliorated oxidative damages measured as 4-hydroxy-2-nonenal (4HNE) and nitrotyrosine in skeletal muscle. In parallel, resveratrol augmented the expression level and activity of SIRT1 and phosphorylation levels of Foxo3a and Akt while suppressed the increases in protein abundances of p53, Bax, MAFbx, and ubiquitin, enzymatic activities of caspase 3 and 20S proteasome, and apoptotic DNA fragmentation in the compressed muscle. These favorable myoprotective effects of resveratrol were diminished upon pharmacological blockade of SIRT1 by using sirtinol. These novel data support the hypothesis that the anti-apoptotic and anti-catabolic effects of resveratrol on compression injury in skeletal muscle required the action of SIRT1.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationFrontiers in physiology, 21 Oct. 2015, v. 6, 293, p. 1-10-
dcterms.isPartOfFrontiers in physiology-
dcterms.issued2015-10-21-
dc.identifier.isiWOS:000366737800001-
dc.identifier.scopus2-s2.0-84946575216-
dc.identifier.eissn1664-042Xen_US
dc.identifier.artn293en_US
dc.identifier.rosgroupid2015001627-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journalen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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