Please use this identifier to cite or link to this item:
Title: Isolation and identification of metabolites of bakuchiol in rats
Authors: Wang, PL
Zhang, FX
Qiu, ZC
Yao, ZH
Wong, MS 
Yao, XS
Dai, Y
Keywords: Bakuchiol
HKC-8 cytotoxicity
MC3T3-E1 cell ALP activity
Psoralea corylifolia
Issue Date: 2016
Publisher: Elsevier
Source: Fitoterapia, 2016, v. 109, p. 31-38 How to cite?
Journal: Fitoterapia 
Abstract: Bakuchiol, the main active component of Psoralea corylifolia, showed a range of significant pharmacological activities, including antimicrobial, antiinflammatory, reduction of bone loss and estrogenic activities. In this research, 12 metabolites, including 11 new compounds, were isolated from the urine and feces of rats after oral administration of bakuchiol, and their structures were elucidated by extensive spectroscopic analysis. The possible metabolic pathways of bakuchiol in rats were proposed, and a rare bile acid conjugation reaction was found. In addition, bakuchiol and its metabolites M1-M3 were studied for their alkaline phosphatase (ALP) activities on MC3T3-E1 cells and cytotoxicity on HKC-8 cells. The data showed that bakuchiol exerted significant effects on ALP activity of MC3T3-E1 cells and cytotoxicity on HKC-8 cells, while M1-M3 only showed ALP activities at 10- 5 M on MC3T3-E1 cells and no cytotoxicity on HKC-8 cells.
ISSN: 0367-326X
DOI: 10.1016/j.fitote.2015.11.006
Appears in Collections:Journal/Magazine Article

View full-text via PolyU eLinks SFX Query
Show full item record

Page view(s)

Last Week
Last month
Checked on Feb 19, 2017

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.