Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43545
Title: Isolation and identification of metabolites of bakuchiol in rats
Authors: Wang, PL
Zhang, FX
Qiu, ZC
Yao, ZH
Wong, MS 
Yao, XS
Dai, Y
Keywords: Bakuchiol
HKC-8 cytotoxicity
MC3T3-E1 cell ALP activity
Metabolites
Psoralea corylifolia
Issue Date: 2016
Publisher: Elsevier
Source: Fitoterapia, 2016, v. 109, p. 31-38 How to cite?
Journal: Fitoterapia 
Abstract: Bakuchiol, the main active component of Psoralea corylifolia, showed a range of significant pharmacological activities, including antimicrobial, antiinflammatory, reduction of bone loss and estrogenic activities. In this research, 12 metabolites, including 11 new compounds, were isolated from the urine and feces of rats after oral administration of bakuchiol, and their structures were elucidated by extensive spectroscopic analysis. The possible metabolic pathways of bakuchiol in rats were proposed, and a rare bile acid conjugation reaction was found. In addition, bakuchiol and its metabolites M1-M3 were studied for their alkaline phosphatase (ALP) activities on MC3T3-E1 cells and cytotoxicity on HKC-8 cells. The data showed that bakuchiol exerted significant effects on ALP activity of MC3T3-E1 cells and cytotoxicity on HKC-8 cells, while M1-M3 only showed ALP activities at 10- 5 M on MC3T3-E1 cells and no cytotoxicity on HKC-8 cells.
URI: http://hdl.handle.net/10397/43545
ISSN: 0367-326X
DOI: 10.1016/j.fitote.2015.11.006
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