Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43485
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dc.contributorDepartment of Rehabilitation Sciences-
dc.creatorLee, TMC-
dc.creatorSun, D-
dc.creatorWong, NML-
dc.creatorShao, R-
dc.creatorMen, W-
dc.creatorGe, J-
dc.creatorSo, KF-
dc.creatorGao, JH-
dc.creatorChan, CCH-
dc.date.accessioned2016-06-07T06:16:26Z-
dc.date.available2016-06-07T06:16:26Z-
dc.identifier.issn2352-3964en_US
dc.identifier.urihttp://hdl.handle.net/10397/43485-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rightsThe following publication Lee, T. M., Sun, D., Wong, N. M., Shao, R., Men, W., Ge, J., ... & Chan, C. C. (2015). A pontine region is a neural correlate of the human affective processing network. EBioMedicine, 2(11), 1799-1805, is available at https://doi.org/10.1016/j.ebiom.2015.10.020en_US
dc.subjectEmotionen_US
dc.subjectFMRIen_US
dc.subjectPonsen_US
dc.subjectRaphe nucleien_US
dc.subjectSmall-world connectivityen_US
dc.titleA pontine region is a neural correlate of the human affective processing networken_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1799en_US
dc.identifier.epage1805en_US
dc.identifier.volume2en_US
dc.identifier.issue11en_US
dc.identifier.doi10.1016/j.ebiom.2015.10.020en_US
dcterms.abstractThe in vivo neural activity of the pons during the perception of affective stimuli has not been studied despite the strong implications of its role in affective processing. To examine the activity of the pons during the viewing of affective stimuli, and to verify its functional and structural connectivity with other affective neural correlates, a multimodal magnetic resonance imaging methodology was employed in this study. We observed the in vivo activity of the pons when viewing affective stimuli. Furthermore, small-world connectivity indicated that the functional connectivity (FC) between the pons and the cortico-limbic affective regions was meaningful, with the coefficient λ being positively associated with self-reported emotional reactivity. The FC between the pons and the cortico-limbic-striatal areas was related to self-reported negative affect. Corroborating this finding was the observation that the tract passing through the pons and the left hippocampus was negatively related to self-reported positive affect and positively correlated with emotional reactivity. Our findings support the framework that the pons works conjunctively with the distributed cortico-limbic-striatal systems in shaping individuals' affective states and reactivity. Our work paves the path for future research on the contribution of the pons to the precipitation and maintenance of affective disorders.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationEBioMedicine, 2015, v. 2, no. 11, p. 1799-1805-
dcterms.isPartOfEBioMedicine-
dcterms.issued2015-
dc.identifier.scopus2-s2.0-84958950424-
dc.identifier.rosgroupid2015005673-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validate201901_a bcmaen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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