Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43325
Title: Age and sex differences in rates of influenza-associated hospitalizations in Hong Kong
Authors: Wang, XL
Yang, L 
Chan, KH
Chan, KP
Cao, PH
Lau, EHY
Peiris, JSM
Wong, CM
Keywords: Age distribution
Hospitalization
Influenza
Risk assessment
Sex
Issue Date: 2015
Publisher: Oxford University Press
Source: American journal of epidemiology, 2015, v. 182, no. 4, p. 335-344 How to cite?
Journal: American journal of epidemiology 
Abstract: Few studies have explored age and sex differences in the disease burden of influenza, although men and women probably differ in their susceptibility to influenza infections. In this study, quasi-Poisson regression models were applied to weekly age- and sex-specific hospitalization numbers of pneumonia and influenza cases in the Hong Kong SAR, People's Republic of China, from 2004 to 2010. Age and sex differences were assessed by age- and sex-specific rates of excess hospitalization for influenza A subtypes A(H1N1), A(H3N2), and A(H1N1)pdm09 and influenza B, respectively. We found that, in children younger than 18 years, boys had a higher excess hospitalization rate than girls, with the male-to-female ratio of excess rate (MFR) ranging from 1.1 to 2.4. MFRs of hospitalization associated with different types/subtypes were less than 1.0 for adults younger than 40 years except for A(H3N2) (MFR = 1.6), while all the MFRs were equal to or higher than 1.0 in adults aged 40 years or more except for A(H1N1)pdm09 in elderly persons aged 65 years or more (MFR = 0.9). No MFR was found to be statistically significant (P < 0.05) for hospitalizations associated with influenza type/subtype. There is some limited evidence on age and sex differences in hospitalization associated with influenza in the subtropical city of Hong Kong.
URI: http://hdl.handle.net/10397/43325
ISSN: 0002-9262
DOI: 10.1093/aje/kwv068
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