Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43157
Title: Highly Enantioselective addition of in situ prepared Arylzinc to Aldehydes catalyzed by a series of Atropisomeric Binaphthyl-Derived Amino Alcohols
Authors: Lu, G
Kwong, FY 
Ruan, JW
Li, YM
Chan, ASC
Keywords: Amino alcohols
Arylation
Arylzinc
Binaphthyl
Enantioselectivity
Issue Date: 2006
Publisher: Wiley-VCH
Source: Chemistry - a European journal, 2006, v. 12, no. 15, p. 4115-4120 How to cite?
Journal: Chemistry - a European journal 
Abstract: The direct addition of in situ prepared arylzinc to aldehydes with chiral binaphthyl-derived amino alcohols as catalysts can afford optically active diarylmethanols in high yields and with excellent enantioselectivities (up to 99 % ee, ee=enantiomeric excess). By using a single catalyst, both enantiomers of many pharmaceutically interesting diarylmethanols can be obtained by the proper combination of various arylzinc reagents with different aldehydes; this catalytic system also works well for the phenylation of aliphatic aldehydes to give up to 96 % ee.
URI: http://hdl.handle.net/10397/43157
ISSN: 0947-6539 (print)
1521-3765 (online)
DOI: 10.1002/chem.200501048
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