Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43062
Title: Pharmacological effects of the dansylated neuropeptide FF analogues on body temperature and Morphine Analgesia
Authors: Fang, Q
He, F
Wang, YQ
Guo, J
Zhang, BZ
Chen, Q
Wang, R
Keywords: Neuropeptide FF (NPFF)
Analogue
Dansylated
Hypothermia
The mouse tail-flick test
Issue Date: 2007
Publisher: Churchill Livingstone
Source: Neuropeptides (Edinburgh), 2007, v. 41, no. 5, p. 339-347 How to cite?
Journal: Neuropeptides (Edinburgh) 
Abstract: In our previous work, the two putative agonists (dansyl-GSRFamide and dansyl-PQRFamide) and the two putative antagonists (dansyl-GSRamide and dansyl-PQRamide) on neuropeptide FF (NPFF) receptors were synthesized to evaluate the importance of Phe8 of NPFF. In the present study, these putative NPFF agonists/antagonists containing different N-terminal sequences were further examined for their pharmacological profiles in thermoregulatory and nociceptive tests. The results indicated that the two dansylated agonists potently possessed similar thermoregulation (rank order of potencies: dansyl-GSRFamide ≫ NPFF > dansyl-PQRFamide) and different modulation of opioid-induced analgesia; in contrast, both of the two putative antagonists exhibited marked hypothermia (rank order of potencies: dansyl-PQRamide > dansyl-GSRamide) and facilitation of morphine analgesia (rank order of potencies: dansyl-PQRamide > dansyl-GSRamide). These data reveal that the difference of the N-terminal residues of the two putative agonists causes their dissociation of pharmacological pro- and anti-opioid effects. In addition, their N-terminal part is important to determine the potency of the dansylated agonists/antagonists. Our work might be helpful to develop a highly potent and fluorescent NPFF ligand.
URI: http://hdl.handle.net/10397/43062
ISSN: 0143-4179 (print)
1532-2785 (online)
DOI: 10.1016/j.npep.2007.04.001
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