Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43024
Title: Frequency tuning and firing pattern properties of auditory thalamic neurons : an in vivo intracellular recording from the guinea pig
Authors: Zhang, Z
Yu, YQ
Liu, CH
Chan, YS
He, JF
Keywords: Single-units
Medial geniculate body
Frequency tuning
Excitatory postsynaptic potential
Inhibitory postsynaptic potential
Resting membrane potential
Firing pattern
Issue Date: 2008
Publisher: Pergamon Press
Source: Neuroscience, 2008, v. 151, no. 1, p. 293-302 How to cite?
Journal: Neuroscience 
Abstract: We investigated the firing pattern and frequency tuning properties of medial geniculate body (MGB) neurons, through in vivo intracellular recordings in anesthetized guinea pigs. Twenty-two of the 25 physiological characterized neurons were anatomically identified. Ten neurons were located in the ventral division of the medial geniculate body (MGv) (seven in pars ovoidea (OV) and three in the pars lateralis (LV)). Eight were located in the dorsal division (MGd), and four in the medial division (MGm). OV neurons showed a uniform, phasic ON response with high frequency selectivity. Functionally, they are interpreted as relaying spectral information with high reliability. LV neurons exhibited various patterns: phasic, tonic and excitatory postsynaptic potentials (EPSP) with a spike train. These high magnitude EPSPs are proposed to convey temporal information of the auditory signals with more encoding power. MGd neurons had relatively low best frequencies while MGm neurons had high intensity threshold, broader frequency selectivity, and a tonic response pattern. Tonic firing is likely to impose a strong impact onto wide cortical area and amygdala. When hyperpolarized with current injection, MGB neurons evoked low-threshold calcium spikes. Distinct change in these spike numbers was observed among MGv and MGd neurons as compared with MGm neurons, implying their differential roles. MGm neurons are more modulatory in nature, while the long lasting bursts of low-threshold calcium spikes observed in MGv and MGd neurons probably participate in propagating the sleep oscillations.
URI: http://hdl.handle.net/10397/43024
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2007.09.082
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

WEB OF SCIENCETM
Citations

8
Last Week
0
Last month
Citations as of Jun 23, 2017

Page view(s)

18
Last Week
1
Last month
Checked on Jun 25, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.