Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/40902
Title: Measurement of diabetic wounds with optical coherence tomography-based air-jet indentation system and a material testing system
Authors: Choi, MC
Cheung, KK
Ng, GYF 
Zheng, YP 
Cheing, GLY 
Keywords: Biomechanical properties
Diabetic wound
Rat model
OCT-based air-jet indentation system
Issue Date: 2015
Publisher: Mark Allen Group
Source: Journal of wound care, 2015, v. 24, no. 11, p. 519-528 How to cite?
Journal: Journal of wound care 
Abstract: OBJECTIVE: Material testing system is a conventional but destructive method for measuring the biomechanical properties of wound tissues in basic research. The recently developed optical coherence tomography-based air-jet indentation system is a non-destructive method for measuring these properties of soft tissues in a non-contact manner. The aim of the study was to examine the correlation between the biomechanical properties of wound tissues measured by the two systems.
METHOD: Young male Sprague-Dawley rats with streptozotocin-induced diabetic were wounded by a 6 mm biopsy punch on their hind limbs. The biomechanical properties of wound tissues were assessed with the two systems on post-wounding days 3, 7, 10, 14, and 21. Wound sections were stained with picro-sirius red for analysis on the collagen fibres. Data obtained on the different days were charted to obtain the change in biomechanical properties across the time points, and then pooled to examine the correlation between measurements made by the two devices. Qualitative analysis to determine any correlation between indentation stiffness measured by the air-jet indentation system and the orientation of collagen fibres.
RESULTS:The indentation stiffness is significantly negatively correlated to the maximum load, maximum tensile stress, and Young's modulus by the material testing system (all p<0.05). The orientation of collagen changes with the indentation stiffness over time.
CONCLUSION:Our findings support the use of optical coherence tomography-based air-jet indentation system to evaluate the biomechanical properties of wounds in a non-contact manner. It is a potential clinical device to examine the biomechanical properties of chronic wounds in vivo in a repeatable manner.
URI: http://hdl.handle.net/10397/40902
ISSN: 0969-0700
DOI: 10.12968/jowc.2015.24.11.519
Appears in Collections:Journal/Magazine Article

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