Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/36280
Title: Highly selective and sensitive nucleic acid detection based on polysaccharide-functionalized silver nanoparticles
Authors: Yan, JK
Ma, HL
Cai, PF
Wu, JY 
Keywords: Polysaccharide
Silver nanoparticles
Nucleic acid detection
Fluorescent sensing platform
Issue Date: 2015
Publisher: Elsevier
Source: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2015, v. 134, p. 17-21 How to cite?
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 
Abstract: Polysaccharide-functionalized silver nanoparticles (Oc-AgNPs) with a mean diameter of 15 nm were utilized as a novel and effective fluorescence-sensing platform for nucleic acid detection. Tests on the oligonucleotide sequences associated with the human immunodeficiency virus as a model system showed that the Oc-AgNPs effectively absorbed and quenched dye-labeled single-stranded DNA through strong hydrogen bonding interactions and slight electrostatic attractive interactions. The proposed system efficiently differentiated between complementary and mismatched nucleic acid sequences with high selectivity and good reproducibility at room temperature.
URI: http://hdl.handle.net/10397/36280
ISSN: 1386-1425
DOI: 10.1016/j.saa.2014.06.079
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