Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/36265
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorSchool of Nursing-
dc.creatorLee, PH-
dc.date.accessioned2016-04-15T08:36:59Z-
dc.date.available2016-04-15T08:36:59Z-
dc.identifier.urihttp://hdl.handle.net/10397/36265-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http:// creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.rightsThe following publication Lee, P. Should we adjust for a confounder if empirical and theoretical criteria yield contradictory results? A simulation study. Sci Rep 4, 6085 (2015) is available at https://dx.doi.org/10.1038/srep06085en_US
dc.titleShould we adjust for a confounder if empirical and theoretical criteria yield contradictory results? A simulation studyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume4-
dc.identifier.doi10.1038/srep06085-
dcterms.abstractConfounders can be identified by one of two main strategies: empirical or theoretical. Although confounder identification strategies that combine empirical and theoretical strategies have been proposed, the need for adjustment remains unclear if the empirical and theoretical criteria yield contradictory results due to random error. We simulated several scenarios to mimic either the presence or the absence of a confounding effect and tested the accuracy of the exposure-outcome association estimates with and without adjustment. Various criteria (significance criterion, Change-in-estimate(CIE) criterion with a 10% cutoff and with a simulated cutoff) were imposed, and a range of sample sizes were trialed. In the presence of a true confounding effect, unbiased estimates were obtained only by using the CIE criterion with a simulated cutoff. In the absence of a confounding effect, all criteria performed well regardless of adjustment. When the confounding factor was affected by both exposure and outcome, all criteria yielded accurate estimates without adjustment, but the adjusted estimates were biased. To conclude, theoretical confounders should be adjusted for regardless of the empirical evidence found. The adjustment for factors that do not have a confounding effect minimally effects. Potential confounders affected by both exposure and outcome should not be adjusted for.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationScientific reports, 15 2014, v. 4, no. , p. 1-14-
dcterms.isPartOfScientific reports-
dcterms.issued2014-
dc.identifier.isiWOS:000340711400005-
dc.identifier.scopus2-s2.0-84906224740-
dc.identifier.pmid25124526-
dc.identifier.eissn2045-2322-
dc.identifier.rosgroupid2014000615-
dc.description.ros2014-2015 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
Lee_Adjust_Confounder_Contradictory.pdf1.24 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

98
Last Week
1
Last month
Citations as of Mar 24, 2024

Downloads

50
Citations as of Mar 24, 2024

SCOPUSTM   
Citations

83
Last Week
0
Last month
Citations as of Mar 28, 2024

WEB OF SCIENCETM
Citations

77
Last Week
1
Last month
Citations as of Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.