Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/35964
Title: Allicin protects rat cardiomyoblasts (H9c2 cells) from hydrogen peroxide-induced oxidative injury through inhibiting the generation of intracellular reactive oxygen species
Authors: Chan, JYY
Tsui, HT
Chung, IYM
Chan, RYK
Kwan, YW
Chan, SW
Keywords: Allicin
Antioxidant
Cardiovascular disease
Health products
Reactive oxygen species
Issue Date: 2014
Publisher: Taylor & Francis
Source: International journal of food sciences and nutrition, 2014, v. 65, no. 7, p. 868-873 How to cite?
Journal: International journal of food sciences and nutrition 
Abstract: Oxidative stress is considered an important factor that promotes cell death in response to a variety of pathophysiological conditions. This study investigated the antioxidant properties of allicin, the principle ingredient of garlic, on preventing oxidative stress-induced injury. The antioxidant capacities of allicin were measured by using 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and hydrogen peroxide (H2O2)-induced cell damage on H9c2 cardiomyoblasts. Allicin (0.3-10 mu M) pre-incubation could concentration-dependently attenuate the intracellular reactive oxygen species (ROS) increase induced by H2O2 on H9c2 cells. It could also protect H9c2 cells against H2O2-induced cell damage. However, the DPPH free radical scavenging activity of allicin was shown to be low. Therefore, it is believed that the protective effect of allicin on H9c2 cells could inhibit intracellular ROS production instead of scavenging extracellular H2O2 or free radicals. For the observed protective effect on H9c2 cells, allicin might also be effective in reducing free radical-induced myocardial cell death in ischemic condition.
URI: http://hdl.handle.net/10397/35964
ISSN: 0963-7486
EISSN: 1465-3478
DOI: 10.3109/09637486.2014.925428
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

8
Last Week
0
Last month
Citations as of Sep 19, 2017

WEB OF SCIENCETM
Citations

8
Last Week
1
Last month
Citations as of Sep 21, 2017

Page view(s)

31
Last Week
1
Last month
Checked on Sep 25, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.