Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/35951
Title: Self-aggregated nanoparticles of carboxylic curdlan-deoxycholic acid conjugates as a carrier of doxorubicin
Authors: Yan, JK
Ma, HL
Chen, X
Pei, JJ
Wang, ZB
Wu, JY 
Keywords: Carboxylic curdlan
Deoxycholic acid
Self-aggregated nanoparticles
Issue Date: 2015
Publisher: Elsevier
Source: International journal of biological macromolecules, 2015, v. 72, p. 333-340 How to cite?
Journal: International journal of biological macromolecules 
Abstract: In this study, a new non-toxic, biodegradable, biocompatible and water-soluble carboxylic curdlan bearing the dissociable COOH group in 100% purity, which was prepared by 4-acetamido-TEMPO-mediated oxidation, was hydrophobically modified by deoxycholic acid (DOCA) to attain novel amphiphilic curdlan derivatives (CCDs) for the preparation of nano-carriers for antitumor drug doxorubicin (DOX). Under the effect of ultrasonication, the carboxylic curdlan derivatives in water were self-aggregated into spherical nanoparticles with diameters ranging from 214 nm to 380 nm. The critical aggregation concentrations decreased from 0.047 mg/mL to 0.016 mg/mL with increasing DS of DOCA. DOX-loaded CCD nanopartides were prepared in an aqueous medium with dialysis method. The DOX-CCD nanoparticles exhibited pH- and dose-dependent drug release profiles during in vitro release experiments. Moreover, the drug transport mechanism was Fickian diffusion according to the Ritger Peppas model. The CCD nanopartides might be explored as potential carriers for hydrophobic drugs with controlled release and delivery functions.
URI: http://hdl.handle.net/10397/35951
ISSN: 0141-8130
DOI: 10.1016/j.ijbiomac.2014.08.035
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